一 基本情况
李启明，博士，副教授，河南周口人。中国微循环学会转化医学专业委员会青年工作委员会委员。联系邮箱：liqiming82@126.com
二 教育经历
2008.09-2012.06 河南农业大学 生物工程
2012.09-2018.06 西南大学 微生物学
2016.12-2018.03 美国罗格斯大学 联合培养博士生
2018.09-至今 河南大学基础医学院
三 主要研究方向
主要研究领域：结核分枝杆菌耐药机理；汉坦病毒与宿主互作过程中的关键分子鉴定与作用机理。
四 承担项目
1. 河南省高等学校重点科研项目计划 2020.01-2021.12 3万元 主持
五 近年研究成果
1. Hong, Yuzhi#; Li, Qiming#; Gao, Qiong; Xie, Jianping; Huang, Haihui; Drlica, Karl; Zhao, Xilin. "Reactive oxygen species play a dominant role in all pathways of rapid quinolone-mediated killing. " Journal of Antimicrobial Chemotherapy (2019) Accept. (共同第一作者)
2. Li, Qiming, Longxiang Xie, Quanxin Long, Jinxiao Mao, Hui Li, Mingliang Zhou, and Jianping Xie. "Proteasome Accessory Factor C (pafC) Is a novel gene Involved in Mycobacterium Intrinsic Resistance to broad-spectrum antibiotics-Fluoroquinolones." Scientific reports 5 (2015): 11910.
3. Li, Qiming, Mingliang Zhou, Xiangyu Fan, Jianlong Yan, Weimin Li, and Jianping Xie. "Mycobacteriophage SWU1 gp39 can potentiate multiple antibiotics against Mycobacterium via altering the cell wall permeability." Scientific reports 6 (2016).
4. Li, Qiming, Tiwei Fu, Chunyan Li, Xiangyu Fan, and Jianping Xie. "Mycobacterial IclR family transcriptional factor Rv2989 is specifically involved in isoniazid tolerance by regulating the expression of catalase encoding gene katG." RSC Advances 6, no. 60 (2016): 54661-54667.
5. Li, Qiming, Chunyan Li, Longxiang Xie, Chenhui Zhang, Yonghong Feng, and Jianping Xie. "Characterization of a putative ArsR transcriptional regulator encoded by Rv2642 from Mycobacterium tuberculosis." Journal of Biomolecular Structure and Dynamics 35, no. 9 (2017): 2031-2039.
6. Li, Hui#, Qiming Li#, Zhaoxiao Yu, Mingliang Zhou, and Jianping Xie. "Mycobacterium tuberculosis PE13 (Rv1195) manipulates the host cell fate via p38-ERK-NF-κB axis and apoptosis." Apoptosis 21, no. 7 (2016): 795-808. （共同第一作者）
7. Lin, Yanping#, Qiming Li#, Longxiang Xie, and Jianping Xie. "Mycobacterium tuberculosis Rv1400c encodes functional lipase/esterase." Protein expression and purification 129 (2017): 143-149. （共同第一作者）
8. Teng Tieshan#, Li Qiming#, Liu Zhengguo, Li Xianghui, et al: Characterization and genome analysis of novel Klebsiella phage Henu1 with lytic activity against clinical strains of Klebsiella pneumoniae. Archives of Virology 2019. （共同第一作者）
9. Abdalla, Abualgasim Elgaili, Qiming Li, Longxiang Xie, and Jianping Xie. "Biology of IL-27 and its role in the host immunity against Mycobacterium tuberculosis." International journal of biological sciences 11, no. 2 (2015): 168.
10. Li, Chunyan, Qiming Li, Yuan Zhang, Zhen Gong, Sai Ren, Ping Li, and Jianping Xie. "Characterization and function of Mycobacterium tuberculosis H37Rv Lipase Rv1076 (LipU)." Microbiological Research 196 (2017): 7-16.
11. Ren, Sai, Qiming Li, Longxiang Xie, and Jianping Xie. "Molecular mechanisms underlying the function diversity of ArsR family metalloregulator." Critical Reviews™ in Eukaryotic Gene Expression 27, no. 1 (2017).
12. Li, Hui, Qiming Li, Wu Li, Longxiang Xie, Mingliang Zhou, and Jianping Xie. "The Role of PARP-1 in Host− Pathogen Interaction and Cellular Stress Responses." Critical Reviews™ in Eukaryotic Gene Expression 25, no. 2 (2015).
13. Xie, Longxiang, Wei Liu, Qiming Li, Shudan Chen, Mengmeng Xu, Qinqin Huang, Jie Zeng, Mingliang Zhou, and Jianping Xie. "First succinyl-proteome profiling of extensively drug-resistant Mycobacterium tuberculosis revealed involvement of succinylation in cellular physiology." Journal of proteome research 14, no. 1 (2014): 107-119.
14. Xie, Longxiang, Xiaobo Wang, Jie Zeng, Mingliang Zhou, Xiangke Duan, Qiming Li, Zhen Zhang et al. "Proteome-wide lysine acetylation profiling of the human pathogen Mycobacterium tuberculosis." The international journal of biochemistry & cell biology 59 (2015): 193-202.
15. Xie, Longxiang, Guirong Wang, Zhaoxiao Yu, Mingliang Zhou, Qiming Li, Hairong Huang, and Jianping Xie. "Proteome-wide lysine glutarylation profiling of the mycobacterium tuberculosis H37Rv." Journal of proteome research 15, no. 4 (2016): 1379-1385.
16. Huang, Qinqin, Hongping Luo, Minqiang Liu, Jie Zeng, Abualgasim Elgaili Abdalla, Xiangke Duan, Qiming Li, and Jianping Xie. "The effect of Mycobacterium tuberculosis CRISPR-associated Cas2 (Rv2816c) on stress response genes expression, morphology and macrophage survival of Mycobacterium smegmatis." Infection, Genetics and Evolution 40 (2016): 295-301.
17. Yan, Shuangquan, Mengmeng Xu, Xiangke Duan, Zhaoxiao Yu, Qiming Li, Longxiang Xie, Xiangyu Fan, and Jianping Xie. "Mycobacteriophage putative GTPase-activating protein can potentiate antibiotics." Applied microbiology and biotechnology100, no. 18 (2016): 8169-8177.
18. Yu, Zhaoxiao, Chenhui Zhang, Mingliang Zhou, Qiming Li, Hui Li, Wei Duan, Xue Li, Yonghong Feng, and Jianping Xie. "Mycobacterium tuberculosis PPE44 (Rv2770c) is involved in response to multiple stresses and promotes the macrophage expression of IL-12 p40 and IL-6 via the p38, ERK, and NF-κB signaling axis." International Immunopharmacology 50 (2017): 319-329.
19. Yan, Shuangquan, Mengmeng Xu, Rui Wang, Qiming Li, Zhaoxiao Yu, and Jianping Xie. "Overexpression of Rv2788 increases mycobacterium stresses survival." Microbiological research 195 (2017): 51-59.
20. 张旭,陈冬东,叶志强,李启明,谢建平.从多组学数据挖掘结核病关键基因的综合策略[J].工程数学学报, 2018(05):515-522
21. Gong Zhen, Kuang Zhongmei, Li Hui, Li Chunyan, Ali Md Kaisar, Huang Fujing, Li Ping, Li Qiming, Huang Xue, Ren Sai, Li Jiang, Xie Jianping. Regulation of host cell pyroptosis and cytokines production by Mycobacterium tuberculosis effector PPE60 requires LUBAC mediated NF-κB signaling. Cell Immunol. 2018
22. Yan Shuangquan, Zhen Junfeng, Li Yue, Zhang Chenhui, Stojkoska A, Lambert N, Li Qiming, Li Ping, Xie Jianping. Mce-associated protein Rv0177 alters the cell wall structure of Mycobacterium smegmatis and promotes macrophage apoptosis via regulating the cytokines. Int Immunopharmacol. 2018 Nov 22;66:205-214.
