一、基本情况
姓名： 王泽坤 性别：男 职称：教授
籍贯： 河北保定
联系方式：18567045926 watearth@foxmail.com
学会任职： 美国病毒学会会员，美国基因与细胞治疗学会会员，河南省微生物学会理事
二、教育经历
2002.9-2006.7 河北大学，生命科学学院，生物技术，理学学士
2006.9-2011.7 复旦大学，上海医学院，病原生物学，理学博士
三、工作经历（含博士后）
2011.7-2012.9 上海交通大学，上海市肿瘤研究所，助理研究员
2012.9-2018.6 美国堪萨斯大学医学中心，微生物与免疫系，博士后
2018.06-至今 河南大学基础医学院 教授
四、教学、研究领域
教学：本科生（医学微生物学），研究生（分子病毒学）
研究方向：布尼亚病毒复制与致病机理，病毒载体分子生物学，基因治疗，抗烈性病毒抗体开发
主要技术特长：分子病毒学
招生专业：病原生物学，药学
五、研究成果
1. 发表论文：
1. Zekun Wang, Songyang Ren, Qiming Li, Austin D Royster, Lei Lin, Sichen Liu, Safder S Ganaie, Jianming Qiu, Sheema Mir, Mohammad A Mir. Hantaviruses use the endogenous host factor P58IPK to combat the PKR antiviral response. PLOS Pathogens. 2021 Oct 15;17(10):e1010007.
2. Wang Z, Cheng F, Engelhardt JF, Yan Z, Qiu J. Development of a Novel Recombinant Adeno-Associated Virus Production System Using Human Bocavirus 1 Helper Genes. Mol Ther Methods Clin Dev. 2018 Oct 4;11:40-51.
3. Zekun Wang, Xuefeng Deng, Wei Zou, John Engelhardt, Ziying Yan, Jianming Qiu. Human Bocavirus 1 Is a Novel Helper for Adeno-Associate Virus Replication. Journal of virology. September 2017 vol. 91 no. 18 e00710-17（亮点论文）
4. Zekun Wang, Weiran Shen, Fang Cheng, Xuefeng Deng, John Engelhardt, Ziying Yan and Jianming Qiu. Parvovirus expresses a small noncoding RNA that plays an essential role in virus replication. Journal of virology. April 2017 vol. 91 no. 8e02375-16. （亮点论文）
5. Zekun Wang, Mohammad A Mir. Andes virus nucleocapsid protein interrupts protein kinase R dimerization to counteract host interference in viral protein synthesis. Journal of virology. February 2015 vol. 89 no. 3 1628-1639.
6. Zekun Wang, Jinjing Ni, Jianhua Li, Bisheng Shi, Yang Xu, Zhenghong Yuan. Inhibition of hepatitis B virus replication by cIAP2 involves accelerating the ubiquitin proteasome mediated destruction of polymerase. Journal of virology. November 2011 vol. 85 no. 21 11457-11467.
7. LiliCao ShengdeLiu YunfeiLi GuangYang YujieLuo SijiLi HongqiangDu YingchiZhao DandanWang JingxuanChen ZemingZhang MoLi SongyingOuyang XiangGao YujieSun Zekun Wang LongYang RongtuanLin FupingYou The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers. Cell Host &Microbe. PMID:31513772 DOI: 10.1016/j.chom.2019.08.010
8. Weiran Shen, Zekun Wang, Kang Ning, Fang Cheng, John F Engelhardt, Ziying Yan, Jianming Qiu. Hairpin Transfer-Independent Parvovirus DNA Replication Produces Infectious Virus. Journal of virology. 2021 Sep 27;95(20):e0110821.
9. Xu P, Ganaie SS, Wang X, Wang Z, Kleiboeker S, Horton NC, Heier RF, Meyers MJ, Tavis JE, Qiu J. Endonuclease Activity Inhibition of the NS1 Protein of Parvovirus B19 as a Novel Target for Antiviral Drug Development. Antimicrob Agents Chemother. 2018 Dec 10. pii: AAC.01879-18.
10. Wei Zou, Zekun Wang, Min Xiong, Aaron Chen, Peng Xu, Safder Ganaie, Yomna Badawi, Steve Kleiboeker, Hiroshi Nishimune, Shui Qing Ye, and Jianming Qiu. Human Parvovirus B19 Utilizes Cellular DNA Replication Machinery for Viral DNA Replication. Journal of virology. 2018 Feb 12;92(5). e01881-17.
11. Wang Y, Wang Z, Pramanik A, Santiago ML, Qiu J, Stephens EB. A chimeric human APOBEC3A protein with a three amino acid insertion confers differential HIV-1 and adeno-associated virus restriction. Virology. 2016 Aug 29; 498: 149-163.
12. Erdong Cheng, Zekun Wang and Mohammad A Mir. Interaction between Hantavirus Nucleocapsid Protein (N) and RNA Dependent RNA Polymerase (RdRp) mutant reveals the requirement of N-RdRp interaction for Viral RNA Synthesis. Journal of virology. August 2014 vol. 88 no. 15 8706-8712.
13. Xuefeng Deng, Wei Zou, Min Xiong, Zekun Wang, John F. Engelhardt, Shui Qing Ye, Ziying Yan, Jianming Qiu. Human Parvovirus Infection of Human Airway Epithelia Induces Pyroptotic Cell Death via Inhibiting Apoptosis. Journal of virology. 2017 Nov 30;91(24). e01533-17.
14. Ziying Yan, Zehua Feng, Xingshen Sun, Yulong Zhang, Wei Zou, Zekun Wang, Chandler Jensen-Cody, Bo Liang, Soo-Yeun Park, Jianming Qiu, John F Engelhardt. Human Bocavirus Type-1 Capsid Facilitates the Transduction of Ferret Airways by Adeno-Associated Virus Genomes. Human Gene Therapy. August 2017, 28(8): 612-625.
15. Jianhua Li, Yinghui Liu, Zekun Wang, Kuancheng Liu, Yaohui Wang, Jiangxia Liu, Huanping Ding, Zhenghong Yuan. Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment. Journal of virology. July 2011 vol. 85 no. 13 6319-6333.
16. Qi-Ying Chen, Ying-Hui Liu, Jian-Hua Li, Ze-Kun Wang, Jiang-Xia Liu, Zheng-Hong Yuan. DNA-dependent activator of interferon-regulatory factors inhibits hepatitis B virus replication. World J Gastroenterology 2012 June 14; 18(22): 2850-2858.
17. Guanglin Bian, Yuming Cheng, Zekun Wang, Yunwen Hu, Xiaonan Zhang, Min Wu, Zhiao Chen, Bisheng Shi, Shuhui Sun, Yan Shen, Er jia Chen, Xin Yao,Yumei Wen, Zhenghong Yuan. Whole recombinant Hansenula polymorpha expressing hepatitis B virus surface antigen (yeast-HBsAg) induces potent HBsAg-specific Th1 and Th2 immune responses. Vaccine 28:187-94.
2. 专利：
Ziying Yan, John F. Engelhardt, Jianming Qiu, Zekun Wang, BOCAPARVOVIRUS SMALL NONCODING RNA AND USES THEREOF 已公开 国际专利申请号16477762
3. 所获荣誉及奖励：
2018.5.16-19 第21届美国基因与细胞治疗学会年会（Travel Award）
2015.7.11-15 第34届美国病毒学会年会（Travel Award）
六、承担项目
1. 2020.1-2023.12 博卡病毒NP1和BocasR基因辅助腺相关病毒复制的机制研究 面上 （主持）58万
2. 2018年河南大学杰出人才特区支持计划人才基金（主持）200万
3. 2016-2017 美国堪萨斯大学医学中心先导基础研究项目：Innate immune response of human airway epithelium to respiratory virus infection （主持）2 万美元
七、参会情况
2019.7 第十三届全国病毒学学术研讨会 哈尔滨 大会报告
2018.6 XVIIth 细小病毒国际研讨会 迈阿密 大会报告
2018.5.16-19 第21届美国基因与细胞治疗学会年会 芝加哥 大会报告（获当期大会资助奖）
2017.5.8-12 第20届美国基因与细胞治疗学会年会 华盛顿
2017.6.24-28 第36届美国病毒学会年会 威斯康星-麦迪逊 大会报告
2015.7.11-15 第34届美国病毒学会年会 加拿大安大略 大会报告（获当期大会资助奖）
2009.9 第25届乙型肝炎病毒分子生物学国际会议 法国图尔斯 墙报
