一 基本情况
胡延忠，博士，教授，黄河学者，博士生导师。
主要研究领域为眼病相关抗体，分子伴侣与老年病。以通讯作者和第一作者发表SCI论文40余篇，主持国家自然科学基金4项，主持省级项目4项，获河南省科技进步二、三等奖各1项，获河南省教育厅科技成果一等奖2项，获国家发明专利3项。
二 教育经历（倒序）
1. 1993-9 至 1996-7, 北京协和医科大学, 生物物理, 博士
2. 1987-9 至 1990-7, 河南医科大学, 微生物与免疫, 硕士
3. 1980-9 至 1983-7, 河南焦作卫校, 临床医学, 学士
博士后工作经历：
1 1996-10 至 2000-1, Karolinska Instutite, Stockholm, Sweden
三 主要研究方向
1. 眼病相关抗体
2. 分子伴侣与老年病
四 承担项目
1. 国家自然科学基金面上项目，热休克转录因子4对晶状体纤维细胞分化双刃剑调控机制，2016/01-2019/12，57万，主持
2. NSFC－河南省联合基金，热休克转录因子4对话自噬－溶酶体通路调控晶状体内稳态, 2017/01-2019/12，46万，主持
3. 河南省科技厅公关计划，靶向热休克转录因子4药物筛选及对白内障的防治，2016.1-2017.12, 10万元，主持
4. 河南省高等学校重点科研项目计划，热休克转录因子4作为防治老年白内障新靶向的理论研究及应用，2015.01-2016.12，主持
5. 河南省眼器官退行性疾病创新型科技团队 2016年， 主持
6. 河南省高校科技创新团队支持计划，分子伴侣与老年性疾病研究，2014/01-2016/12，100万元，主持
7. 国家自然科学基金面上项目，热休克转录因子 1 作为癌靶蛋白在肝细胞癌中的分子调控机理，2009/01-2012/12，30万元，主持
8. 国家自然科学基金面上项目，热休克转录因子4基因突变致先天性白内障分子机理研究，2008/01-2011/12，29万元，主持
五 已发表论文（近5年）
1. Weikai Guo, Manjie Wang, Zhengfan Yang, Danyang Liu, Borui Ma, Yanqun Zhao, Yihua Chen, Yanzhong Hu, Recent advances in small molecule and peptide inhibitors of glucose-regulated protein 78 for cancer therapy, Eur J Med Chem, 2023 Dec 5: 261: 115792.
2. Jing Zhang, Ping Li, Luqian Sun, Ning Jiang, Wenya Guo, Jungai Wang, Fen Gao, Jing Li, Hui Li, Jun Zhang, Hongmei Mu, Yanzhong Hu#, Xiukun Cui#. Knockout of miR-184 in zebrafish leads to ocular abnormalities by elevating p21 levels. The FASEB Journal. 2023;37: e22927.
3. Yuhang Zhang, Xuyan Peng, Mengjiao Xue, Jingjing Liu, Guohui Shang, Mingjun Jiang, Dandan Chen, Baixue Liu, Yuxuan Wang, Xiaolin Jia, Jianqing Xu, Fengyan Zhang, Yanzhong Hu, SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway, Biogerontology, 2023 Feb 4;1-15.
4. Dan-Dan Chen, Baixue Liu, Yuxuan Wang, Mingjun Jiang, Guohui Shang, Mengjiao Xue, Xiaolin Jia, YouFei Lang, Guiling Zhou, Fengyan Zhang, Xuyan Peng, Yanzhong Hu, The downregulation of HSP90-controlled CRALBP expression is associated with age-related vision attenuation, FASEB J, 2023 Mar;37(3): e22832.
5. Jing Zhang, Min Jing, Ping Li, Luqian Sun, Xiahui Pi, Ning Jiang, Ke-Ke Zhu, Hui Li, Jing Li, Mingli Wang, Jun Zhang, Mugen Liu, Hongmei Mu, Yanzhong Hu#, Xiukun Cui#, Knockout of DLIC1 leads to retinal cone degeneration via disturbing Rab8 transport in zebrafish, Biochim Biophys Acta Mol Basis Dis. 2023 Apr;1869(4):166645.
6. Zhengyan Yang, Wenjuan Wan, Pai Zhang, Shuangfeng Wang, Zhi Zhao, Jingrui Xue, Mengzhuo Yao, Yiwei Zhao, Weifeng Zheng, Baohua Niu, Mingli Wang, Hui Li, Weikai Guo, Zhiguang Ren, Yanzhong Hu, Crosstalk between heat shock factor 1 and signal transducer and activator of transcription 3 mediated by interleukin-8 autocrine signaling maintains the cancer stem cell phenotype in liver cancer, J Gastroenterol Hepatol. 2023 Jan;38(1):138-152.
7. Jing Li, Jingjing Yu, Weikang Huang, Fan Sang, Junmin Li, Yanzhu Ren, Huili Huang, Mingli Wang, Kejia Li, Jun Zhang, Hui Li, Xiukun Cui, Jing Zhang, Mengyue Hu, Fengling Yuan, Weikai Guo, Fengyan Zhang, Hongmei Mu and Yanzhong Hu#, Extracellular HSP90 promotes differentiation of lens epithelial cells to fiber cells by activating LRP1-YAP-PROX1 axis, FASEB Journal, 2023 Feb;37(2): e22783.
8. Jing Zhang, Hongying Gao, Ning Jiang, Min Jing, Ziwei Sun, Chunxiao Du, Jun Zhang, Mingli Wang, Jing Li, Fen Gao, Yanzhong Hu, Hongmei Mu, Xiukun Cui, Retinitis pigmentosa 2 pathogenic mutants degrade through BAG6/HUWE1 complex, Exp Eye Res. 2022 Jul;220:109110.
9. Mingli Wang, Jialin Hu, Junwei Qu, Huili Huang, Jing Zhang, Jun Zhang, Hui Li, Xiukun Cui, Fengyan Zhang, Meng Yue Hu, Jing Li, Yanzhong Hu, The Therapeutic Roles of Recombinant Hsp90α on Cornea Epithelial Injury, Invest Ophthalmol Vis Sci, 2022 Feb 1;63(2):30.
10. Longjun Yan, Jing Li, Jialin Hu, Junwei Qu, Kejia Li, Mingli Wang, Shuang-Shuang An, Cun-Cun Ke, Hui Li, Fengling Yuan, Weikai Guo, Mengyue Hu, Jing Zhang, Zhengyan Yang, Hongmei Mu, Fengyan Zhang, Jun Zhang, Xiukun Cu, Yanzhong Hu, Biotin attenuates heat shock factor 4b transcriptional activity by lysine 444 biotinylation, Biochem Biophys Rep, 2022 Feb 5;30:101227.
11. Dan-Dan Chen, Xuyan Peng, Yuxuan Wang, Mingjun Jiang, Mengjiao Xue, Guohui Shang, Xuhui Liu, Xiaolin Jia, Baixue Liu, Yingwei Lu, Hongmei Mu, Fengyan Zhang, Yanzhong Hu, HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells, Aging (Albany NY), 2021 Sep 8;13(17):21547-21570.
12. Xiukun Cui, Chunxiao Du, Simin Wan, Dandan Wu, Longjun Yan, Jing Zhang, Jing Li, Hui Li, Zhengyan Yang, Hailong Zhang, Jun Zhang, Hongmei Mu, Fengyan Zhang, Xuyan Peng, Mugen Liu, Yanzhong Hu, Deficiency of heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21 cip1 expression, Biochim Biophys Acta Mol Basis Dis, 2021, 1867(11): 166233.
13. Jing Li, Jingjing Yu, Wenxian Xue, Huili Huang, Longjun Yan, Fan Sang, Shuangshuang An, Jing Zhang, Mingli Wang, Jun Zhang, Hui Li, Xiukun Cui, Jiang He, Yanzhong Hu, The engineered expression of secreted HSPB5-Fc in CHO cells exhibits cytoprotection in vitro, BMC Biotechnology, 2021, 21(1): 39.
14. Xiukun Cui, Ruiping Feng, Jungai Wang, Chunxiao Du, Xiahui Pi, Danling Chen, Jing Li, Hui Li, Jun Zhang, Jing Zhang, Hongmei Mu, Fengyan Zhang, Mugen Liu, Yanzhong Hu, Heat shock factor 4 regulates lysosome activity by modulating the αB-crystallin-ATP6V1A-mTOR complex in ocular lens, Biochim Biophys Acta Gen Subj, 2020 Mar;1864(3):129496.
15. Jing Zhang, Wen-wen Cui, Chunxiao Du, Yuwen Huang, Xiahui Pi, Wenya Guo, Jungai Wang, Weikang Huang, Danling Chen, Jing Li, Hui Li, Jun Zhang, Yuanfang Ma, Hongmei Mu, Mugen Liu, Xiukun Cui, Yanzhong Hu. Knockout of DNase1l1l abrogates lens denucleation process and causes cataract in zebrafish, BBA-Molecular Basis of Disease 2020, 1866(5):165724.
16. Jing Li, Wenxian Xue, Xuance Wang, Weikang Huang, Xiangxiang Wang, Hui Li, Xiukun Cui, Mengyuan Li, Hongmei Mu, Yanzhu Ren, Fengyan Zhang and Yanzhong Hu, HSP90 as a novel therapeutic target for posterior capsule opacification, Eye Research experiment, 2019, 189: 107821.
17. Zhang J, Gao F, Du C, Wang J, Pi X, Guo W, Li J, Li H, Ma Y, Zhang W, Mu H, Hu Y# and Cui, X.#, A novel RP2 missense mutation Q158P identified in an X-linked retinitis pigmentosa family impaired RP2 protein stability, Gene, 2019, 707:86-92.
六 获得奖励
1. 胡延忠（1/7），热休克转录因子转录调控机制理论研究，河南省科技进步三等奖，河南省科技厅，2019.01
2. 胡延忠（1/8），热休克转录因子转录调控机制理论研究，科技成果一等奖，河南省教育厅，2018.05
3. 胡延忠（1/7），白内障-热休克反应失调致病机制理论研究，河南省科学技术进步二等奖，河南省科技厅，2016.12
4. 胡延忠（1/5），热休克因子靶向治疗的分子机制，科技成果一等奖，河南省教育厅，2016.05
