一 基本情况
崔秀坤，博士，副教授，山东沂水人。河南省医学会眼科学分会第一届眼科基础研究和临床转化学组委员。
二 教育经历
2003.09-2007.06 曲阜师范大学 生物技术 本科
2007.09-2009.06 华中科技大学 遗传学 硕士
2009.09-2013.06 华中科技大学 遗传学 博士
2013.07-至今 河南大学
三 主要研究方向
主要带教课程：医学遗传学；
主要研究领域：遗传性眼病的致病机制研究和靶向药物研发。
四 承担项目
1. 模式生物研究Hsf4b/T472磷酸化修饰障碍诱发白内障的分子机理(81400387), 国家自然科学基金青年项目, 23万元，2015.01-2017.12，主持
2. 热休克因子4感应蛋白质内稳态调控晶状体发育的机制研究(81770911)，国家自然科学基金面上项目，56万元，2018.01-2021.12，主持
五 近年研究成果
1. Zhang J, Gao F, Du C, Wang J, Pi X, Guo W, Li J, Li H, Ma Y, Zhang W, Mu H, Hu Y, Cui X. A novel RP2 missense mutation Q158P identified in an X-linked retinitis pigmentosa family impaired RP2 protein stability. Gene. 2019 May 6; 707:86-92. doi: 10.1016/j.gene.2019.05.006. JCR 3区，IF 2.8
2. Xiukun Cui, Jiuli Han, Jing Li, et al., Downregulation of heat shock factor 4 transcription activity via MAPKinase phosphorylation at Serine 299. Int J Biochem Cell Biol, 2018 Oct 11;105:61-69. doi: 10.1016/j.biocel.2018.10.003. JCR 2区，IF 3.5
3. Cui Xiukun#, Zhou Zheng#, Zhu Keke#, et al., A Novel Cx50 Insert Mutation from a Chinese Congenital Cataract Family Impairs Its Cellular Membrane Localization and Function. DNA Cell Biol. 2018 May;37(5):449-456. doi: 10.1089/dna.2017.4051. JCR 3区，IF 2.8
4. Xiukun Cui, Wenxiu Han, Jing Li, et al., Heat shock factor 4 regulates the expression of HSP25 and alpha B-crystallin by associating with DEXD/H-box RNA helicase UAP56. Cell Stress Chaperones. 2018 Jul;23(4):571-579. doi: 10.1007/s12192-017-0865-y. JCR 3区，IF 2.9
5. Xiu-Kun Cui#, Ke-Ke Zhu#, Zheng Zhou, et al., A novel frameshift mutation in CX46 associated with hereditary dominant cataracts in a Chinese family. Int J Ophthalmol 2017;10(5):684-690. doi: 10.18240/ijo.2017.05.04. JCR 4区，IF 1.2
6. Cui Xiukun#，Liu Huiyuan#，Li Jing，et al.，Heat shock factor 4 regulates lens epithelial cell homeostasis by working with lysosome and anti-apoptosis pathways.，Int J Biochem Cell Biol，2016，79：118-127. doi: 10.1016/j.biocel.2016.08.022. JCR 2区，IF 3.9
7. Cui Xiukun#, Xie Panpan, Jia Panpan, et al., Hsf4 counteracts Hsf1 transcription activities and increases lens epithelial cell survival in vitro. Biochimica et Biophysica Acta-Molecular Cell Research, 2015, 1853(3):746-755. doi: 10.1016/j.bbamcr.2015.01.004. JCR 2区，IF 4.9
8. Zhang Jing#, Cui Xiukun#, Wang Lei, et al., The mitochondrial thioredoxin is required for liver development in zebrafish. Curr Mol Med. 2014;14(6):772-82. DOI: 10.2174/1566524014666140724103927. JCR 2区，IF 4.2（Co-first）
9. Xiukun Cui#, Lei Wang#, Jing Zhang#, et al., HSF4 Regulates DLAD Expression and Promotes Lens Denucleation. Biochim Biophys Acta-Molecular Basis of Disease, 1832 (2013) 1167-1172. doi: 10.1016/j.bbadis.2013.03.007. JCR 2区，IF 5.0
10. Xiukun Cui#, Jing Zhang#, Du Rong#, et al., HSF4 is involved in DNA damage repair through regulation of Rad51. Biochim Biophys Acta-Molecular Basis of Disease 1822 (2012) 1308-1315. doi: 10.1016/j.bbadis.2012.05.005. JCR 2区，IF 5.1
11. Xiukun Cui#, Feng Zeng#, Ying Liu, et al., A novel SCN1A missense mutation causes generalized epilepsy with febrile seizures plus in a Chinese family. Neurosci Lett 503 (2011) 27-30. doi: 10.1016/j.neulet.2011.08.001. JCR 4区，IF 1.9
12. Tailan Zhan#, Xiukun Cui#, Xuenong Xing, et al., Mucolipidosis in a Chinese family with compound heterozygous mutations at the GNPTAB gene. Clin Chim Acta 412 (2011) 1469-1471. doi: 10.1016/j.cca.2011.04.025. JCR 3区，IF 2.6（Co-first）
