一 基本情况
杨争艳,博士,副教授,河南济源人。
二 教育经历
2003.09-2008.06 河南大学, 临床医学, 学士
2009.09-2012.06 河南大学, 医学免疫学, 硕士, 导师:马远方
2012.09-2015.06 中国人民解放军军事科学院军事医学研究院,博士,导师:郭宁
2015.07-至今 河南大学医学院,教师
三 主要研究方向
主要带教课程:病理学,口腔组织病理学;
四 承担项目
1. 国家自然科学基金青年基金,81803575,甲硫哒嗪逆转胃癌赫赛汀耐药的作用和分子机制,2019/01-2021/12,21.00万,在研,主持
2. 河南省高等学校重点科研项目计划,19A310006,甲硫达嗪逆转肿瘤耐药的作用和机制研究,2019.01-2020.12,3.00万元,在研,主持
3. 开封市科技发展计划,1908009,D2DR活化诱导Skp2表达上调及在胃癌靶向治疗耐药中的意义,2019/01-2020/12,立项支持,在研,主持
4. 河南大学科学研究基金,2016YBZR046,基于SKP2抑制的甲硫哒嗪逆转胃癌赫赛汀耐药的分子机制,2016/01-2017/12,0.5万元,结题,主持
5. 2019年河南大学医学院青年人才科研培育计划项目,2019014,曲妥珠单抗在Her2阳性胃癌细胞中的耐药机制及逆转策略,2019.7-2020.12,5万元,在研,主持
6. 国家自然科学基金面上项目,3177050277,O-GlcNAc转移酶Ogt在抗病毒天然免疫反应中的作用及其机制研究,2018.01-2021.12,83.1万元,在研,参加
7. 国家重点研发计划,2017YFD0501705,大熊猫与虎重要疫病流行病学与病原朔源技术研究,2017.07-2020.12,34万元,在研,参加
8. 国家自然科学基金面上项目,31370825,儿茶酚胺诱导Her2分子加工的机制及在肿瘤转移中的意义,2014.01-2017.12,90.00万元,结题,参加
9. 国家自然科学基金青年科学基金项目,30901766,靶向ErbB2功能表位的新型拮抗肽的设计及体内外功能评价,2010.01-2012.12,20.00万元,结题,参加
五 近年研究成果
1. Liu, D(#),Yang, Z(#),Wang, T(#),Yang, Z,Chen, H,Hu, Y,Hu, C,Guo, L,Deng, Q,Liu, Y,Yu, M,Shi, M(*),Du, N(*),Guo, N(*),beta2-AR signaling controls trastuzumab resistance-dependent pathway,Oncogene,2016,35(1):47-58.(IF: 8.459,一区)
2. Yang, Zhengyan(#),Guo, Liang(#),Liu, Dan,Sun, Limin,Chen, Hongyu,Deng, Que,Liu, Yanjun,Yu, Ming,Ma, Yuanfang,Guo, Ning(*),Shi, Ming(*),Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/ Notch positive feedback loop,Oncotarget,2015,6(7):5072-5087.(IF: 6.359,二区)
3. Shi, Ming (#),Yang, Zhengyan(#),Hu, Meiru(#),Liu, Dan,Hu, Yabin,Qian, Lu,Zhang, Wei,Chen, Hongyu,Guo, Liang,Yu, Ming,Song, Lun,Ma, Yuanfang(*),Guo, Ning(*),Catecholamine-Induced beta2-adrenergic receptor activation mediates desensitization of gastric cancer cells to trastuzumab by upregulating MUC4 expression,J Immunol,2013,190(11):5600-5608.(IF: 5.52,二区)
4. Shi, Ming(#)(*),Liu, Dan,Yang, Zhengyan,Guo, Ning(*),Central and peripheral nervous systems: master controllers in cancer metastasis,Cancer Metastasis Rev,2013,32(3-4):603-621.(IF: 7.79,二区)
5. Liu, Dan(#),Deng, Que(#),Sun, Limin,Wang, Tao,Yang, Zhengyan,Chen, Hongyu,Guo, Liang,Liu, Yanjun,Ma, Yuanfang,Shi, Ming(*),Guo, Ning(*),A Her2-let-7-beta2-AR circuit affects prognosis in patients with Her2-positive breast cancer,BMC Cancer,2015,10(15):832-865.(IF: 3.3,三区)
6. Chen, Hongyu(#),Liu, Dan (#),Sun, Limin, Yang, Zhengyan,Deng, Que,Yang, Shuo,Qian, Lu,Guo, Liang,Yu, Ming,Hu, Meiru,Shi, Ming(*),Guo, Ning(*),Adrenergic signaling promotes angiogenesis through endothelial cell-tumor cell crosstalk. Endocrine-Related Cancer,2014,21(5):783-795.(IF: 4.43, 二区)
7. Liu, Dan(#),Shi, Ming(#),Duan, Chenyang(#),Chen, Hongyu,Hu, Yabin,Yang, Zhengyan,Duan, Huijun,Guo, Ning(*),Downregulation of Erbin in Her2-overexpressing breast cancer cells promotes cell migration and induces trastuzumab resistance,Molecular Immunology,2013,56(1-2):104-112.(IF: 2.92,三区)
8. Shi, Ming(#),Zhao, Mingzhen (#),Hu, Meiru,Liu, Dan,Cao, Hong,Qian, Lu,Yang, Zhengyan,Hu, Yabin,Yu, Ming,Yang, Shuo,Ma, Yuanfang(*),Guo, Ning(*),beta2-AR-induced Her2 transactivation mediated by Erbin confers protection from apoptosis in cardiomyocytes,International Journal of Cardiology,2013,167(4):1570-1577.(IF: 6.8,二区)
9. Hu, Y(#),Chen, H(#),Duan, C,Liu, D,Qian, L,Yang, Z,Guo, L,Song, L,Yu, M,Hu, M,Shi, M,Guo, N(*),Deficiency of Erbin induces resistance of cervical cancer cells to anoikis in a STAT3- dependent manner,Oncogenesis,2013,2(6):e52.(二区)
10. Shi, Ming(#),Du, Libin(#),Liu, Dan,Qian, Lu,Hu, Meiru,Yu, Ming,Yang, Zhengyan,Zhao, Mingzhen,Chen, Changguo,Guo, Liang,Wang, Lina,Song, Lun,Ma, Yuanfang(*),Guo, Ning(*),Glucocorticoid regulation of a novel HPV-E6-p53-miR-145 pathway modulates invasion and therapy resistance of cervical cancer cells,Journal of Pathology,2012,228(2):148-157.(IF: 7.27,一区)