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眼病相关抗体

杨争艳

2019年10月21日         作者:         访问:[]

基本情况

杨争艳,博士,副教授,河南济源人。

教育经历

2003.09-2008.06   河南大学, 临床医学, 学士

2009.09-2012.06   河南大学, 医学免疫学, 硕士, 导师:马远方

2012.09-2015.06   中国人民解放军军事科学院军事医学研究院,博士,导师:郭宁

2015.07-至今      河南大学医学院,教师

主要研究方向

主要带教课程:病理学,口腔组织病理学;

承担项目

1.      国家自然科学基金青年基金,81803575,甲硫哒嗪逆转胃癌赫赛汀耐药的作用和分子机制,2019/01-2021/1221.00万,在研,主持

2.      河南省高等学校重点科研项目计划,19A310006,甲硫达嗪逆转肿瘤耐药的作用和机制研究,2019.01-2020.123.00万元,在研,主持

3.      开封市科技发展计划,1908009D2DR活化诱导Skp2表达上调及在胃癌靶向治疗耐药中的意义,2019/01-2020/12,立项支持,在研,主持

4.      河南大学科学研究基金,2016YBZR046,基于SKP2抑制的甲硫哒嗪逆转胃癌赫赛汀耐药的分子机制,2016/01-2017/120.5万元,结题,主持

5.      2019年河南大学医学院青年人才科研培育计划项目,2019014,曲妥珠单抗在Her2阳性胃癌细胞中的耐药机制及逆转策略,2019.7-2020.12,5万元,在研,主持

6.      国家自然科学基金面上项目,3177050277O-GlcNAc转移酶Ogt在抗病毒天然免疫反应中的作用及其机制研究,2018.01-2021.1283.1万元,在研,参加

7.      国家重点研发计划,2017YFD0501705,大熊猫与虎重要疫病流行病学与病原朔源技术研究,2017.07-2020.1234万元,在研,参加

8.      国家自然科学基金面上项目,31370825,儿茶酚胺诱导Her2分子加工的机制及在肿瘤转移中的意义,2014.01-2017.1290.00万元,结题,参加

9.      国家自然科学基金青年科学基金项目,30901766,靶向ErbB2功能表位的新型拮抗肽的设计及体内外功能评价,2010.01-2012.1220.00万元,结题,参加

近年研究成果

1.      Liu, D(#)Yang, Z(#)Wang, T(#)Yang, ZChen, HHu, YHu, CGuo, LDeng, QLiu, YYu, MShi, M(*)Du, N(*)Guo, N(*)beta2-AR signaling controls trastuzumab resistance-dependent pathwayOncogene2016351):47-58.IF: 8.459,一区)

2.      Yang, Zhengyan(#)Guo, Liang(#)Liu, DanSun, LiminChen, HongyuDeng, QueLiu, YanjunYu, MingMa, YuanfangGuo, Ning(*)Shi, Ming(*)Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/ Notch positive feedback loopOncotarget201567):5072-5087.IF: 6.359,二区)

3.      Shi, Ming (#)Yang, Zhengyan(#)Hu, Meiru(#)Liu, DanHu, YabinQian,  LuZhang, WeiChen, HongyuGuo, LiangYu, MingSong, LunMa, Yuanfang(*)Guo, Ning(*)Catecholamine-Induced beta2-adrenergic receptor activation mediates desensitization of gastric cancer cells to trastuzumab by upregulating MUC4 expressionJ Immunol201319011):5600-5608.IF: 5.52,二区)

4.      Shi, Ming(#)(*)Liu, DanYang, ZhengyanGuo, Ning(*)Central and peripheral nervous systems: master controllers in cancer metastasisCancer Metastasis Rev2013323-4):603-621.IF: 7.79,二区)

5.      Liu, Dan(#)Deng, Que(#)Sun, LiminWang, TaoYang, ZhengyanChen, HongyuGuo, LiangLiu, YanjunMa, YuanfangShi, Ming(*)Guo, Ning(*)A Her2-let-7-beta2-AR circuit affects prognosis in patients with Her2-positive breast cancerBMC Cancer20151015):832-865.IF: 3.3,三区)

6.      Chen, Hongyu(#)Liu, Dan (#)Sun, Limin Yang, ZhengyanDeng, QueYang, ShuoQian, LuGuo, LiangYu, MingHu, MeiruShi, Ming(*)Guo, Ning(*)Adrenergic signaling promotes angiogenesis through endothelial cell-tumor cell crosstalk. Endocrine-Related Cancer2014215):783-795.IF: 4.43, 二区)

7.      Liu, Dan(#)Shi, Ming(#)Duan, Chenyang(#)Chen, HongyuHu, YabinYang, ZhengyanDuan, HuijunGuo, Ning(*)Downregulation of Erbin in Her2-overexpressing breast cancer cells promotes cell migration and induces trastuzumab resistanceMolecular Immunology2013561-2):104-112.IF: 2.92,三区)

8.      Shi, Ming(#)Zhao, Mingzhen (#)Hu, MeiruLiu, DanCao, HongQian, LuYang, ZhengyanHu, YabinYu, MingYang, ShuoMa, Yuanfang(*)Guo, Ning(*)beta2-AR-induced Her2 transactivation mediated by Erbin confers protection from apoptosis in cardiomyocytesInternational Journal of Cardiology20131674):1570-1577.IF: 6.8,二区)

9.      Hu, Y(#)Chen, H(#)Duan, CLiu, DQian, LYang, ZGuo, LSong, LYu, MHu, MShi, MGuo, N(*)Deficiency of Erbin induces resistance of cervical cancer cells to anoikis in a STAT3- dependent mannerOncogenesis201326):e52.(二区)

10.   Shi, Ming(#)Du, Libin(#)Liu, DanQian, LuHu, MeiruYu, MingYang, ZhengyanZhao, MingzhenChen, ChangguoGuo, LiangWang, LinaSong, LunMa, Yuanfang(*)Guo, Ning(*)Glucocorticoid regulation of a novel HPV-E6-p53-miR-145 pathway modulates invasion and therapy resistance of cervical cancer cellsJournal of Pathology20122282):148-157.IF: 7.27,一区)

 

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