一 基本情况
李静,博士研究生,副教授,硕士生导师,河南濮阳人。主要研究领域为眼病相关抗体,分子伴侣与后发性白内障的分子机制和应用研究。主持国自然青年基金1项,省级项目3项,市级项目1项,以第一作者或共同通讯作者发表SCI论文7篇。研究成果获河南省科技进步二等奖1项,获国家发明专利3项。
二 教育经历(倒序)
2008/9 - 2014/7,汕头大学,病理学与病理生理学,博士
2003/9 - 2008/7,海南医学院,预防医学,学士
三 主要研究方向
1. 眼病相关抗体
2. 分子伴侣与后发障
四 承担项目
1. 河南省科技攻关项目,细胞外HSP90蛋白修复淋巴水肿的研究,2022.01-2023.12,主持
2. 河南省医学科技攻关计划,房水微环境HSP90通过TGFβ2调控后发性白内障的分子机制,2021.01-2022.12,主持
3. 国家自然科学基金青年基金,分泌型HSP90通过m6A RNA去甲基化酶FTO促进后发性白内障的机制研究,2020.01-2022.12,21万元,主持
4. 河南省科技攻关项目,靶向晶状体微环境分泌型HSP90抑制后发性白内障的研究,2020.01-2021.12,主持
5. 河南省高等学校重点科研项目计划,热休克转录因子4对年龄相关性白内障的防治及活性化合物筛选,2018.01-2019.12,3万元,主持
五 已发表论文
1. Jing Li, Jingjing Yu, Weikang Huang, Fan Sang, Junmin Li, Yanzhu Ren, Huili Huang, Mingli Wang, Kejia Li, Jun Zhang, Hui Li, Xiukun Cui, Jing Zhang, Mengyue Hu, Fengling Yuan, Weikai Guo, Fengyan Zhang, Hongmei Mu and Yanzhong Hu, Extracellular HSP90 promotes differentiation of lens epithelial cells to fiber cells by activating LRP1-YAP-PROX1 axis, The FASEB Journal, 2023 Feb;37(2): e22783.
2. Mingli Wang, Jialin Hu, Junwei Qu, Huili Huang, Jing Zhang, Jun Zhang, Hui Li, Xiukun Cui, Fengyan Zhang, Meng Yue Hu, Jing Li#, Yanzhong Hu#, The Therapeutic Roles of Recombinant Hsp90α on Cornea Epithelial Injury, Investigative Ophthalmology & Visual Science, 2022 Feb 1; 63(2):30.
3. Longjun Yan*, Jing Li*, Jialin Hu, Junwei Qu, Kejia Li, Mingli Wang, Shuang-Shuang An, Cun-cun Ke, Hui Li, Fengling Yuan, Weikai Guo, Mengyue Hu, Jing Zhang, Zhengyan Yang, Hongmei Mu, Fengyan zhang, Jun Zhang, Xiukun Cui, Yanzhong Hu, Biotin attenuates heat shock factor 4b transcriptional activity by lysine 444 biotinylation, Biochemistry and Biophysics Reports, 2022 Feb 5; 30:101227.
4. Jing Li, Jingjing Yu, Wenxian Xue, Huili Huang, Longjun Yan, Fan Sang, Shuangshuang An, Jing Zhang, Mingli Wang, Jun Zhang, Hui Li, Xiukun Cui, Jiang He, Yanzhong Hu, The engineered expression of secreted HSPB5-Fc in CHO cells exhibits cytoprotection in vitro, BMC Biotechnology, 2021 Jun,14 21(1): 39.
5. Jing Li, Wenxian Xue, Xuance Wang, Weikang Huang, Xiang-Xiang Wang, Hui Li, Xiukun Cui, Mengyuan Li, Hongmei Mu, Yanzhu Ren, Fengyan Zhang, Yanzhong Hu, HSP90 as a novel therapeutic target for posterior capsule opacification, Experimental Eye Research, 2019 Dec, 189: 107821.
6. Jing Li, Yan Zhou, Jiang Gu, Stain-Decolorize-Stain (SDS): a new technique for multiple staining. Histochemistry and Cell Biology, 2014 Mar,141(3): 251-262.
7. Jing Li, Korteweg Christine, Yamei Qiu, Jin Luo, Zhengshan Chen, Guowei Huang, Weiqiu Li, Jiang Gu, Two ultrastructural distribution patterns of immunoglobulin G in human placenta and functional implications. Biology of Reproduction, 2014 Nov, 91(5): p128.
六 获得奖励
1. 李静(3/7),白内障-热休克反应失调致病机制理论研究,河南省科技厅,河南省科学技术进步二等奖,2016.12.26
2. 李静(3/5),热休克因子靶向治疗的分子机制,河南省教育厅,科技成果一等奖,2016.05
3. 李静(4/8),热休克转录因子转录调控机制理论研究,科技成果一等奖,河南省教育厅,2018.05