一、基本情况
赵丹，博士，副教授，河南开封人，中共党员。
二、教育经历
2012.09-2016.06 河北师范大学生命科学学院，生物科学专业，理学学士
2016.09-2021.06 南开大学生命科学学院，生物化学与分子生物学专业，硕博连读，理学博士
三、工作经历
2021年至今 就职于河南大学第一附属医院，同时在抗体药物开发技术国家地方联合工程实验室从事科研工作。
四、主要研究方向
心血管生物学；心梗后细胞损伤机制、心肌损伤后的保护策略、心血管疾病抗体药物研发。
五、参与项目
天津市自然科学基金重点项目“调控NogoB表达在糖脂代谢紊乱疾病中的重要作用与机制研究”（BE123841）。
六、发表论文
[1] Zhao D, Li J, Xue C, Feng K, Liu L, Zeng P, Wang X, Chen Y, Li L, Zhang Z, Duan Y, Han J, Yang X. TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells. J Biol Chem, 2020, 295(48): 16314-16327.
[2] Zhao D#, Xue C#, Li J, Feng K, Zeng P, Chen Y, Duan Y, Zhang S, Li X, Han J, Yang X. Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress. Biochem Biophys Res Commun, 2020, 533(3): 304-312.
[3] Wei Z#, Zhao D#, Zhang Y, Chen Y, Zhang S, Li Q, Zeng P, Li X, Zhang W, Duan Y, Han J, Yang X. Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-kB-TNF-a signaling pathway in a PPARg-dependent manner. Biochem Biophys Res Commun, 2019, 519(4): 854-860.
[4]Chen Y#, Hu W#, Li Q#, Zhao S, Zhao D, Zhang S, Wei Z, Yang X, Chen Y, Li X, Liao C, Han J, Miao QR, Duan Y. NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Apr 1:100624.
[5] Feng K, Ma C, Liu Y, Yang X, Yang Z, Chen Y, Xu T, Yang C, Zhang S, Li Q, Wei Z, Zhao D, Zeng P, Han J, Gao J, Chen Y, Duan Y. Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR-induced lipogenesis. Theranostics, 2021, 11(6): 2634-2654.
[6] Zhang S, Guo F, Yu M, Yang X, Yao Z, Li Q, Wei Z, Feng K, Zeng P, Zhao D, Li X, Zhu Y, Miao Q R, Iwakiri Y, Chen Y, Han J, Duan Y. Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity. J Hepatol, 2020, 73(6): 1482-1495.
[7] Li Q, Chen Y, Zhao D, Yang S, Zhang S, Wei Z, Wang Y, Qian K, Zhao B, Zhu Y, Chen Y, Duan Y, Han J, Yang X. LongShengZhi Capsule reduces carrageenan-induced thrombosis by reducing activation of platelets and endothelial cells. Pharmacol Res, 2019, 144167-180.
[8] Ma J, Zhao D, Wang X, Ma C, Feng K, Zhang S, Chen Y, Zhu Y, Gao X, Zhao B, Wang Y, Qian K, Li X, Duan Y, Han J, Yang X. LongShengZhi Capsule Reduces Established Atherosclerotic Lesions in apoE-Deficient Mice by Ameliorating Hepatic Lipid Metabolism and Inhibiting Inflammation. J Cardiovasc Pharmacol, 2019, 73(2): 105-117.
[9] Li Q, Chen Y, Zhao D, Wei Z, Zhang S, Chen Y, Wang Y, Qian K, Zhao B, Zhu Y, Gao X, Dong P, Li X, Duan Y, Han J, Yang X. NaoXinTong Capsule Inhibits Carrageenan-Induced Thrombosis in Mice. J Cardiovasc Pharmacol, 2018, 72(1): 49-59.
[10] Zhao D, Yang X, Duan Y, Chen Y, Han J. TNF ligand related molecule-1A inhibits atherosclerosis in apoE-deficient mice. The FASEB Journal. 2019 EB, Orlando, FL, USA. 2019/4/6-9. (会议论文)
七、联系方式
邮箱：zhaodan2020nku@163.com
