一 基本情况
张利杰，博士，副教授，河南周口人。
二 教育工作经历
2011.09-2015.06 河南农业大学牧医工程学院动物医学专业，农学学士
2015.09-2020.07 中国农业大学动物医学院预防兽学医学，农学博士
2020.07-至今 河南大学基础医学院抗体药物开发技术国家地方联合工程实验室
三 主要研究方向
主要研究领域：结构生物学；心血管疾病抗体药物研发。
四 承担项目
1. sDR5-Fc融合蛋白减轻心肌缺血再灌注损伤的分子机制研究，212300410107，河南省自然科学基金，2021.01-2022.12，在研，主持。
2. 肿瘤坏死因子相关凋亡诱导配体(TRAIL)重组蛋白的高效表达，20211022013，校级大学生创新创业项目，2021.05-2022.05，指导。
五 近年主要研究成果
1. L. Zhang, X. Li, L. Ma, B. Zhang, G. Meng, and C. Xia. 2020. A Newly Recognized Pairing Mechanism of the α- and β-Chains of the Chicken Peptide–MHC Class II Complex. Journal of immunology 204: 1630-1640.
2. L. Zhang, Y. Liu, G. Meng, R. Liang, B. Zhang, and C. Xia. 2020. Structural and Biophysical Insights into the TCRαβ Complex in Chickens. iScience 23(12):101828.
3. X. Li, L. Zhang, Y. Liu, L. Ma, N. Zhang, and C. Xia. 2020. Structures of MHC-I molecule BF2*1501 illustrate the preferred presentation of an HPAIV H5N1-derived epitope. Journal of Biological Chemistry.
4. R. Chen, L. Zhang, J. Qi, N. Zhang, L. Zhang, S. Yao, Y. Wu, B. Jiang, Z. Wang, H. Yuan, Q. Zhang, and C. Xia. 2018. Discovery and Analysis of Invertebrate IgVJ-C2 Structure from Amphioxus Provides Insight into the Evolution of the Ig Superfamily. Journal of immunology 200: 2869-2881. 封面杂志
5. Z. Li, N. Zhang, L. Ma, L. Zhang, G. Meng, and C. Xia. 2020. The Mechanism of beta2m Molecule-Induced Changes in the Peptide Presentation Profile in a Bony Fish. iScience 23: 101119.
6. Z. Qu, Z. Li, L. Ma, X. Wei, L. Zhang, R. Liang, G. Meng, N. Zhang, and C. Xia. 2019. Structure and Peptidome of the Bat MHC Class I Molecule Reveal a Novel Mechanism Leading to High-Affinity Peptide Binding. Journal of immunology 202: 3493-3506. 封面杂志
7. L. Ma, N. Zhang, Z. Qu, R. Liang, L. Zhang, B. Zhang, G. Meng, J. M. Dijkstra, S. Li, and M. C. Xia. 2020. A Glimpse of the Peptide Profile Presentation by Xenopus laevis MHC Class I: Crystal Structure of pXela-UAA Reveals a Distinct Peptide-Binding Groove. Journal of immunology 204: 147-158.
8. J. Wang, N. Zhang, Z. Wang, W. Yanan, L. Zhang, and C. Xia. 2018. Structural insights into the evolution feature of a bony fish CD8alphaalpha homodimer. Molecular immunology 97: 109-116.
六 联系方式
zhanglijie@henu.edu.cn
