个人简介：
韩根成，军事医学科学院基础医学研究所研究员，博士生导师。
教育及研究工作主要经历：
2002年毕业于第三军医大学，获免疫学专业博士学位； 2005-2007年在美国路易斯维尔大学从事博士后研究。2002年至今先后任军事医学科学院基础医学研究所助理研究员、副研究员、研究员。
研究方向
一直从事免疫调控异常与疾病的关系研究。早期围绕不同T辅助细胞亚群的调控机制及其在免疫耐受诱导中的应用展开研究，阐明了抗原的不同耐受诱导途径对T细胞亚群分化的影响及意义。近期重点聚焦于免疫细胞稳态调控的机制及意义研究。发现了一些在T细胞及天然免疫细胞稳态调控中发挥关键作用的免疫检查点分子，重点阐明了它们在天然免疫细胞稳态调控中的信号通路，研发了相应的抗体等干预制剂，为后续的应用研究奠定了扎实的理论及实验基础。
课题及成果
先后以负责人承担国家”973”课题2项，国家重点研发计划课题1项，北京市自然科学基金重点项目1项，国家自然科学基金面上项目4项，以及其它多项军事医学项目。
截止目前已经发表SCI研究论文60余篇。其中以通讯或第一作者在Journal of Immunology, Scientific Reports, Cancer Res等专业杂志发表SCI论文35篇，总影响因子160。获得授权国家发明专利8项，国际发明专利（PCT）1项。
社会兼职：
中国免疫学会基础免疫学分会委员；《细胞与分子免疫学杂志》编委，《中国肿瘤生物治疗杂志》编委；Journal of Immunology, Cellular Molecular Immunology 等杂志的审稿人。
附2010年至今发表的SCI研究论文（*通讯作者；#第一作者）
1. Wang Z, Sun D, Chen G, Li G, Dou S, Wang R, Xiao H, Hou C, Li Y, Feng J, Shen B, Han G*. Tim-3 inhibits macrophage control of Listeria monocytogenes by inhibiting Nrf2. Scientific Reports. 2017 Feb 16; 7: 42095.
2. Li Y, Zhou T, Wang Y, Ning C, Lv Z, Han G*, Morris JC, Taylor EN, Wang R, Xiao H, Hou C, Ma Y, Shen B, Feng J, Guo R, Li Y, Chen G. The protumorigenic potential of FTY720 by promoting extramedullary hematopoiesis and MDSC accumulation. Oncogene. 2017 Feb 20. doi: 10.1038/onc.2017.2.
3. Zhang Y, Wang Z, Xiao H, Liu X, Zhu G, Han G, Chen G, Hou C, Ma N, Shen B, Li Y, Wang T, Wang R. Foxd3 suppresses IL-10 expression in B cells. Immunology 2017. Apr. 150(4): 478-488.
4. Ma N, Zhang Y, Liu Q, Wang Z, Liu X, Zhu G, Yu D, Han G, Chen G, Hou C, Wang T, Ma Y, Shen B, Li Y, Xiao H*, Wang R*. B-cell Activating Factor (BAFF) selected IL-10-B cells over IL-10+B Cells in inflammatory response. Mol Immunol. 2017. Feb. 85: 18-26.
5. Jiang X, Zhou T, Xiao Y, Yu J, Dou S, Chen G, Wang R, Xiao H, Hou C, Wang W, Shi Q, Feng J, Ma Y, Shen B, Li Y, Han G*. Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis. OncoImmunology. 2016. Aug 3, 5(9): e1211219.
6. Wang X, Liu X, Zhang Y, Wang Z, Zhu G, Han G, Chen G, Hou C, Wang T, Ma N, Shen B, Li Y, Xiao H*, Wang R*. Interleukin (IL)-39 [IL-23p19/Epstein–Barr virus-induced 3 (Ebi3)] induces differentiation/expansion of neutrophils in lupus-prone mice. Clin Exp Immunol. 2016 Nov. 186 (2): 144-156.
7. Liu X, Zhang Y, Wang Z, Wang X, Zhu G, Han G, Chen G, Hou C, Wang T, Shen B, Li Y, Ma N, Xiao H*, Wang R*. Metabotropic glutamate receptor 3 is involved in B-cell-related tumor apoptosis. Int J Oncol. 2016 Oct. 49 (4): 1469-1478.
8. Wang X, Wei Y, Xiao H, Liu X, Zhang Y, Han G, Chen G, Hou C, Ma N, Shen B, Li Yan, Egwuagu CE*, Wang R. Novel IL-23p19/Ebi3 (IL-39) Cytokine Mediates Inflammation in Lupus-like Mice. Eur J Immunol. 2016 Jun; 46(6): 1343-50.
9. Wang X, Wei Y, Xiao H, Liu X, Zhang Y, Han G, Chen G, Hou C, Zhang L, Ma N, Shen B, Li Y, Egwuagu CE, Wang R. Pre-existing CD19-independent GL7- Breg cells are expanded during inflammation and in mice with lupus-like disease. Mol Immunol. 2016 Mar; 71: 54-63.
10. Jiang X, Yu J, Shi Q, Xiao Y, Wang W, Chen G, Zhao Z, Wang R, Xiao H, Hou C, Feng J, Ma Y, Shen B, Wang L, Li Y, Han G*. Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages. Clin Immunol. 2015 Jul 21; 160: 328–335.
11. Li J, Li M, Su L, Wang H, Xiao K, Deng J, Jia Y, Han G* Xie L.Alterations of T helper lymphocyte subpopulations in sepsis, severe sepsis, and septic shock: a prospective observational study. Inflammation. 2015 Jun;38(3):995-1002.
12. Ren F, Li J, Jiang X, Xiao K, Zhang D, Zhao Z, Ai J, Hou C, Jia Y, Han G*, Xie L. Plasma soluble Tim-3 emerges as an inhibitor in sepsis: sepsis contrary to membrane Tim-3 on monocytes. Tissue Antigens. 2015 Nov;86(5):325-32.
13. Ning C, Li YY, Wang Y, Han GC*, Wang RX, Xiao H, Li XY, Hou CM, Ma YF, Sheng DS, Shen BF, Feng JN, Guo RF, Li Y, Chen GJ. Complement activation promotes colitis-associated carcinogenesis through activating intestinal IL-1β/IL-17A axis. Mucosal Immunol. 2015 Nov; 8(6): 1275-84.
14. Ma N, Liu X, Xing C, Wang X, Wei Y, Han G, Chen G, Hou C, Shen B, Li Y, Xiao H*, Wang R*. Ligation of metabotropic glutamate receptor 3 (Grm3) ameliorates lupus-like disease by reducing B cells. Clin Immunol. 2015 Jun 9; 160(2): 142-154.
15. Wang X, Wei Y, Liu X, Xing Chen, Han G, Chen G, Hou C, Dambuza IM, Shen B, Li Yan, Xiao H，Wang R. IL-15-secreting γδT cells induce memory T cells in experimental allergic encephalomyelitis (EAE) mice. Mol Immunol. 2015 Aug; 66(2): 402-8.
16. Wang X, Xiao H, Wei Y, Liu X, Han G, Chen G, Hou C, Shen B, Li Y, Wang R*. Blockade of B-cell activating factor (BAFF) with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in EAE mice. Central Eur J Immunol. 2015. 40 (2): 142-148
17. Xing C, Ma N, Xiao H, Wang X, Zheng M, Han G, Chen G, Hou C, Shen B, Li Y, Wang R. Critical role for thymic CD19+CD5+CD1dhiIL-10+ regulatory B cells in immune homeostasis. J Leukoc Biol. 2015 Mar; 97(3):547-56.
18. He Y, Ma N, Xing C, Wang X, Xiao H, Zheng M, Han G, Chen G, Hou C, Shen B, Li Y, Jiang Z, Wang R, Wu W. Novel IL-6-secreting γδT (γδT6) cells increased in patients with atherosclerotic cerebral infarction. Mol Med Rep. 2015 Feb; 11(2): 1497-503.
19. Zhao Z, Jiang X, Kang C, Xiao Y, Hou C, Yu J, Wang R, Xiao H, Zhou T, Wen Z, Feng J, Chen G, Ma Y, Shen B, Li Y, Han G*. Blockade of the Tim-3 pathway exacerbates sepsis-induced immune deviation and immunosuppression. Clin Exp Immunol. 2014 Nov. 178 (2): 279-91.
20. Guo X, Jiang X, Xiao Y, Zhou T, Guo Y, Wang R, Zhao Z, Xiao H, Hou C, Ma L, Lin Y, Lang X, Feng J, Chen G, Shen B, Han G*, Li Y. IL-17A signaling in colonic epithelial cells inhibits pro-inflammatory cytokine production by enhancing the activity of ERK and PI3K. PLoS One. 2014. 9: e89714.
21. Wang Y, Han G #, Wang K, Liu G, Wang R, Xiao H, Li X, Hou C, Shen B, Guo R, Li Y, Chen G. Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF. Cancer Res. 2014. 74: 716-726.
22. Wang Y, Wang K, Han GC#, Wang R, Xiao H, Hou CM, Guo RF, Dou Y, Shen BF, Li Y, Chen GJ. Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis. Mucosal Immunol. 2014. Sep. 7(5): 1106-15.
23. Zheng M, Xing C, Xiao H, Ma N, Wang X, Han G, Chen G, Hou C, Shen B, Li Y*, Wang R. Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis. Immunol. Invest. 2014. 43:705-716.
24. Ma N, Xing C, Xiao H, He Y, Han G, Chen G, Hou C, Marrero B, Wang Y, Zhang S, Shen B, Li Y, Wang R. BAFF Suppresses IL-15 Expression in B Cells. J. Immunol. 2014. 192: 4192-4201.
25. Ma N, He Y, Xiao H, Han G, Chen G, Wang Y, Wang K, Hou C, Yang X, Marrero B, Wang Y, Shen B, Li Y, Wang R. BAFF Maintains T-Cell Survival by Inducing OPN Expression in B Cells. Mol. Immunol. 2014. 57: 129-137.
26. Ma N, Xiao H, Marrero B, Xing C, Wang X, Zheng M, Han G, Chen G, Hou C, Shen B, Li Y, Wang R，Jiang Z. Combination of TACI-IgG and Anti-IL-15 Treats Murine Lupus by reducing mature and memory B cells. Cell. Immunol. 2014. 289: 140-144.
27. Yang X, Jiang X, Chen G, Xiao Y, Geng S, Kang C, Zhou T, Li Y, Guo X, Xiao H, Hou C, Wang R, Lin Z, Li X, Feng J, Ma Y, Shen B, Li Y, Han G*. T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response. J. Immunol. 2013. 190: 2068-79.
28. Wang Y, Han G#, Chen Y, Wang K, Liu G, Wang R, Xiao H, Li X, Hou C, Shen B, Guo R, Li Y, Chen G. Protective role of tumor necrosis factor (TNF) receptors in chronic intestinal inflammation: TNFR1 ablation boosts systemic inflammatory response. Lab. Invest. 2013. 93(9):1024-1035.
29. Gencheng Han*, Guojiang Chen, Beifen Shen, Yan Li. Tim-3: An activation marker and activation limiter of innate immune cells. Front. Immunol. 2013 (4):449
30. He Y, Ma N, Xiao H, Xing C, Han G, Chen G, Hou C, Shen B, Li Y, Wang R*, Hu W. BAFF induces the transcription of recombination-activating genes in transitional stage 1 B cells. Centr. Eur. J. Immunol. 2013. 38 (3): 336-342.
31. Ma N, Xing C, Xiao H, Wang Y, Wang K, Hou C, Han G, Chen G, Marrero B, Wang Y, Shen B, Li Y, Wang R. C5a regulates IL-12+DC migration to induce pathogenic Th1 and Th17 cells in sepsis. Plos one. 2013. 8(7): e69779.
32. Wang R, Wang R, Ma N, Guo Y, Xiao H, Chen G, Han G, Hou C, Shen B, Feng J, Li Y. Identify the key amino acid of BAFF binding with TACI. Cell. Immunol. 2013. 284：84-90.
33. Shi F, Guo X, Jiang X, Zhou P, Xiao Y, Zhou T, Chen G, Zhao Z, Xiao H, Hou C, Li X, Yang X, Wang R, Feng J, Shen B, Li Y, Han G*. Dysregulated Tim-3 expression and its correlation with imbalanced CD4 helper T cell function in ulcerative colitis. Clin. Immunol. 2012. 145: 230-40.
34. Wang K, Han G #, Dou Y, Wang Y, Liu G, Wang R, Xiao H, Li X, Hou C, Shen B, Guo R, Li Y, Shi Y, Chen G. Opposite role of tumor necrosis factor receptors in dextran sulfate sodium-induced colitis in mice. PLoS One. 2012. 7: e52924.
35. Han G*, Geng S, Li Y, Chen G, Wang R, Li X, Ma Y, Shen B, Li Y. γδT-cell function in sepsis is modulated by C5a receptor signalling. Immunology. 2011 Jul. 133: 340-9.
36. Li Y, Feng J, Geng S, Geng S, Wei H, Chen G, Li X, Wang L, Wang R, Peng H, Han G*, Shen B, Li Y. The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity. Mol. Immunol. 2011 Jan. 48: 670-7.
37. Yang Y, Wang H, Dou Y, Wang Y, Han G, Wang R, Wang L, Guo R, Xiao H, Li X, Shen B, Shi Y, Chen G, Li Y. Colitogenic role of tumour necrosis factor (TNF) receptors in trinitrobenzene sulphonic acid colitis: TNF-R1 ablation does not affect systemic inflammatory response. Clin. Exp. Immunol. 2011 Sep. 165: 372-82.
38. Chen G, Yang Y, Gao X, Dou Y, Wang H, Han G, Wang R, Wang J, Wang L, Li X, Guo R, Xiao H, Shen B, Li Y. Blockade of complement activation product C5a activity using specific antibody attenuates intestinal damage in trinitrobenzene sulfonic acid induced model of colitis. Lab. Invest. 2011 Mar. 91: 472-83.
39. Xu R, Wang R, Han G #, Wang J, Chen G, Wang L, Li X, Guo R, Shen B, Li Y. Complement C5a regulates interleukine-17 by affecting the crosstalk between DCs and gammadelta T cells in CLP-induced sepsis. Eur. J. Immunol. 2010. 40: 1079-88.
40. Han G*, Wang R, Chen G , Wang J, Xu R, Wang L, Feng J, Li X, Guo R, Fu L, Shen B, Li Y. Interleukin-17-producing gammadelta (+) T cells protect NOD mice from type I diabetes through a mechanism involving transforming growth factor-beta. Immunology. 2010. 129: 197-206.
41. Wang L, Han G, Wang R, Wang J, Chen G, Wang L, Li X, Guo R, Shen B, Li Y. Regulation of IL-8 production by complement activated product, C5a, in vitro and in vivo during sepsis. Clin. Immunol. 2010. 137: 157-65.
42. Li X, Chen G, Li Y, Wang R, Wang L, Lin Z, Gao X, Feng J, Ma Y, Shen B, Li Y, Han G*. Involvement of T cell Ig Mucin-3 (Tim-3) in the negative regulation of inflammatory bowel disease. Clin. Immunol. 2010. 134: 169-177.
附授权发明专利：
1、韩根成，黎燕，沈倍奋，冯健男，郎小玲，蒋兴伟，时凤敏，杨小梅，陈国江，肖鹤，侯春梅。抗人Tim-3的中和性单克隆抗体L3D及其用途，授权时间：2014.05.28,专利号：ZL 201110407008.6;
2、韩根成 陈国江 康春燕 肖燕 谢晓玮 王仁喜 郎小玲 肖鹤 侯春梅 冯健男 蒋兴伟 赵智 黎燕 沈倍奋. 一种检测TIM-3试剂盒及其使用方法. 授权时间：2016.08.17，专利号： ZL201410036781.X
3、韩根成，陈国江，蒋兴伟，王仁喜，肖鹤，侯春梅，于佳卉，赵智，冯健男，黎燕，沈倍奋. 一种能阻断Tim-3 信号通路的人Tim-3融合蛋白. 授权时间：2016.08.24.专利号:ZL 201410036782.4；
4、黎燕，沈倍奋，韩根成，李育蓉，冯健男．增强免疫反应的人半乳凝素－9缺失突变体制备及应用，授权时间：2012.08.08, 专利号:ZL 200910260048.5；
5、黎燕，沈倍奋，王建安，王仁喜，韩根成，宋伦，钱家华，吴小兵，董小岩，曹晖，用于治疗和预防I型糖尿病的重组腺相关病毒及用途，授权时间： 2009.06.03，专利号: ZL200310115504.x；
6、陈国江，韩根成，黎燕，沈倍奋，洪海燕，王仁喜，肖鹤，王一，王柯，侯春梅 一种抗肿瘤蛋白质，授权时间：2014.05.21, 专利号: ZL201310015845.3；
7、王仁喜；黎燕；肖鹤；韩根成；陈国江；侯春梅；沈倍奋；马宁；邢陈。一种治疗系统性红斑狼疮的药物组合物. 授权时间：2015.04.01专利号：ZL 201310120334.8。
8、侯春梅，韩根成，陈国江；王仁喜；肖鹤；黎燕；冯健男；沈倍奋。一种基于DNAH5基因的结肠癌诊断试剂盒。授权时间：2016.09.14；专利号: ZL201510070003.7。
9、授权PCT专利：Han G, Chen G, Kang C, Xiao Y, Xie X, Wang R, Lang X, Xiao H, Hou C,Feng J, Jiang X, Zhao Z, Li Y, Shen B. Human Tim-3 fusion protein capable of blocking Tim-3 signaling pathway. Issue Date: 2017-05-09; Patent No. 9644020.
附作为负责人承担的课题
1. 国家“973 ”项目课题2项 (2007CB512406；2013CB530506)；
2. 国家重点研发计划课题1项（2016YFC1202905）
3. 北京市自然科学基金重点项目1项(7141007);
4. 国家自然科学基金面上项目4项（30571732；81072475；81172800；81471540）
