一 基本情况
魏寅祥,博士,副教授,河南巩义人。
二 教育经历
2016-至今 河南大学基础医学院
2012.09-2016.06 浙江大学,基础医学院免疫所,博士
2009.09-2012.06 河南大学,基础医学院,硕士
2005.09-2009.06 河南师范大学,生命科学学院,学士
三 主要研究方向
主要带教课程:承担临床医学、药学专业医学免疫学相关课程的教学任务;
主要研究领域:无菌性炎症的免疫调控机制;缺血性心肌病发病机制及诊疗抗体开发。
四 承担项目
1. 抗体表达细胞株规模发酵工艺优化及抗体制备,横向课题,2019.3-2019.9,到账经费60万元
五 近年研究成果
1. Wei Y#, Zhang F#, Zhang Y#, Wang X, Xing C, Guo J, Zhang H, Suo Z, Li Y, Wang J, Wang R, Cai Z. Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells. Cell Mol Immunol. 2018 May 29. (PMID: 29844590, DOI: 10.1038/s41423-018-0041-z, JCR II, IF:8.213)
2. Wang X#, Wei Y#, Xiao H#, Liu X, Zhang Y, Han G, Chen G, Hou C, Shen B, Li Yan, Egwuagu CE*, Wang R*. Novel IL-23p19/Ebi3 (IL-39) Cytokine Mediates Inflammation in Lupus-like Mice. Eur J Immunol. 2016 Jun;46(6):1343-50.(PMID: 27019190,DOI: 10.1002/eji.201546095,JCR II,IF:4.695)
3. Wang X#, Wei Y#, Xiao H#, Liu X, Zhang Yu, Han G, Chen G, Hou C, Zhang L, Ma N, Shen B, Li Y, Egwuagu CE*, Wang R*. Pre-existing CD19-independent GL7- Breg cells are expanded during inflammation and in mice with lupus-like disease. Mol Immunol. 2016 Mar;71:54-63. (PMID: 26852110 ,DOI: 10.1016/j.molimm.2016.01.011,JCR II, IF:3.064)
4. Wang X#, Wei Y#, Liu X#, Xing Chen, Han G, Chen G, Hou C, Dambuza IM, Shen B, Li Yan, Xiao H*, Wang R*. IL-15-secreting γδT cells induce memory T cells in experimental allergic encephalomyelitis (EAE) mice. Mol Immunol. 2015 Aug;66(2):402-8. (PMID: 25974878 ,DOI: 10.1016/j.molimm.2015.04.021,JCR II,IF:3.064)
5. Yang F#, Wei Y#, Cai Z, Yu L, Jiang L, Zhang C, Yan H, Wang Q, Cao X, Liang T*, Wang J*.Activated cytotoxic lymphocytes promote tumor progression by increasing the ability of 3LL tumor cells to mediate MDSC chemoattraction via Fas signaling. Cell Mol Immunol. 2015 Jan;12(1):66-76. (PMID: 24769795,DOI: 10.1038/cmi.2014.21,JCR II, IF:8.213)
6. Wang X#, Xiao H#, Wei Y#, Liu X, Han G, Chen G, Hou C, Shen B, Li Y, Wang R*. Blockade of B-cell activating factor (BAFF) with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in EAE mice. Central Eur J Immunol. 2015. 40 (2): 142-148.(PMID: 26557026 ,DOI: 10.5114/ceji.2015.52826, JCR IV, IF:1.455)
7. Ma N#, Liu X#, Xing C#, Wang X, Wei Y, Han G, Chen G, Hou C, Shen B, Li Y, Xiao H*, Wang R*. Ligation of metabotropic glutamate receptor 3 (Grm3) ameliorates lupus-like disease by reducing B cells. Clin Immunol. 2015 Jun 9; 160(2): 142-154.(PMID: 26071318 DOI: 10.1016/j.clim.2015.05.016,JCR II, IF:3.548)
8. 李娜#,魏寅祥,侯春梅,韩根成,陈国江,沈倍奋,冯健男,黎燕,王仁喜*,肖鹤*,雌二醇体外诱导对调节性B细胞分泌IL-10的影响,国际药学研究杂志,2016,03:524-28
9. 魏寅祥,赵青,任志广,贾砚寒,李新颖,黎燕,彭晖*,马远方*, 米哚妥林对P糖蛋白介导的多药耐药的逆转作用, 中国药理学与毒理学杂志,2013,
发明专利
1. 彭晖,魏寅祥,赵青,任志广,冯健男,林周,黎燕,沈倍奋,索拉菲尼在制备逆转肿瘤多药耐药性的药物中的应用,2013.03.27,中国,CN201110156891.6