张纪岩 简历
中国人民解放军军事医学科学院
基础医学研究所（三所)免疫学研究室
研究员 (教授)、博士生导师、实验室副主任
教育经历（按时间倒排序）：
1995.08-2000.07 军事医学科学院基础医学研究所免疫学专业 获博士学位
导师：沈倍奋 院士
1990.09-1995.07 第四军医大学临床医学专业 获学士学位
工作经历（科研与学术工作经历，按时间倒序排序）：
1. 工作经历简况
2010.09-至今 |
军事医学科学院基础医学研究所 |
研究员 |
2006.09-2010.08 |
军事医学科学院基础医学研究所 |
副研究员 |
2003.05-2005.12 |
芝加哥大学Ben-May癌症研究所 |
博士后 |
2000.07-2006.08 |
军事医学科学院基础医学研究所 |
助理研究员 |
2. 主要学术兼职
中国免疫学会理事
中国人民解放军免疫学专业委员会常委
国家自然科学基金委员会医学科学部评审组专家
中国免疫学会英文会刊《Cell Mol Immunol》杂志editor
中国免疫学会中文会刊《中国免疫学杂志》副主编
北京市生物化学学会理事
北京市免疫学会常务理事
军事医学科学院学位审定委员会委员
3. 担任SCI期刊审稿人
Oncotarget
Cancer Lett
Psychoneuroendocrinology
Mol Biol Cell
Cell Mol Immunol
Sci Rep
4. 主要学术荣誉
(1) 2007.12 中国科协“第四届中国青年女科学家奖”；
(2) 2008.08 中国免疫学会“青年学者奖”；
(3) 2008.12 中国人民解放军总后勤部“科技新星”；
(4) 2012.01 中国人民解放军“高层次科技创新拔尖人才”。
5. 参加国内外学术会议
2007.04 河南开封 第六届全军免疫学大会 大会报告
2010.11 浙江嘉兴 第一届中国青年遗传学家论坛 大会报告
2011.12 日本大阪 第二届中日韩免疫学研讨会 大会报告
2012.06 云南昆明 第二届中国青年遗传学家论坛 大会报告
2012.10 重庆 第八届全国免疫学大会 主持分会场并分会报告
2012.11 江苏苏州 国际生理学大会 分会场报告
2013.05 美国檀香山 AAI第100届年会ChSI分会场 大会报告
2013.11 海南三亚 第十届全军免疫学大会 大会报告
2014.10 山东济南 第九届全国免疫学大会 大会报告
2015.11 成都 第四届中德免疫学研讨会 大会报告
6．所获奖励
(1) 北京市科技进步二等奖 (2008)，排名第2
名称：基于受体-配体、抗原-抗体相互作用的立体结构信息设计新功能分子
(2) 2010年中国石油和化学工业优秀科技图书奖二等奖，主编
名称：《分子免疫学实验指南》
7. 国家发明专利
(1) 一种获得调节性巨噬细胞的新方法 (申请号：201310345011.9)
(2) p38a拮抗肽突变体及其应用 (申请号：201510398221.3)
(3) 一种治疗心肌缺血再灌注损伤的药物多肽 (申请号：201510397851.9)
(4) 一种可以治疗心肌缺血再灌注损伤的p38a拮抗肽 (专利号：ZL 2011 1 0187332.1)
(5) 人RACK1与MKK7新功能表位以及用途 (专利号：ZL 2011 1 0071837.1)
8. 主持或参加科研项目及人才计划项目情况（按时间倒序排序）：
序号 |
项目、课题名称 (编号) |
项目类别 |
起止时间 |
经费* (万元) |
作用 |
状态 |
1 |
XXX(秘密级2016YFC1202900) |
“生物安全关键技术”重点专项 |
2016.07- 2018.12 |
308 |
项目负责人 |
在研 |
2 |
新型p38a拮抗肽作为心肌再灌注损伤候选药物的研究 (2013ZX09103003-010) |
“重大新药创制”科技重大专项 |
2013.01- 2015.12 |
136 |
主持 |
结题 |
3 |
慢性心理应激对髓系来源抑制细胞的影响与机制(31270960) |
国家自然科学基金面上项目 |
2013.01- 2016.12 |
80 |
主持 |
在研 |
4 |
RACK1与Nanog相互作用参与肝细胞癌干细胞自我更新的分子机制研究(81472736) |
国家自然科学基金面上项目 |
2015.01- 2018.12 |
74 |
主持 |
在研 |
5 |
免疫细胞信号通路相关蛋白质生物学功能及其作用机制 (2010CB911904) |
国家重点基础研究发展计划 |
2010.01- 2014.12 |
230 |
课题负责人 |
结题 |
6 |
特异阻断p38替代模式活化防治心肌再灌注损伤(7101008) |
北京市自然科学基金重点项目 |
2010.01- 2012.12 |
40 |
主持 |
结题 |
7 |
TAB1/p38a相互作用作为抗炎药物分子设计新靶点的研究 (30973547) |
国家自然科学基金面上项目 |
2010.01- 2012.12 |
33 |
主持 |
结题 |
8 |
p38/TAB1相互作用作为药物设计新靶点的研究 (2009ZX09301-002-001-002) |
“重大新药创制”科技重大专项 |
2009.01- 2011.12 |
150 |
主持 |
结题 |
9 |
第二信使cAMP通过DLC1抑制p38通路活化的分子机制及在炎症调控中的意义 (30671958) |
国家自然科学基金面上项目 |
2007.01- 2009.12 |
26 |
主持 |
结题 |
*申请人所能支配经费
人才基金项目
(1) 2006.01-2006.12 军事医学科学院科技创新研究启动基金, 3万元，已结题；
(2) 2007.11-2010.10 北京市科委“北京市科技新星计划(A类)”，8万元，已结题；
(3) 2008.01-2008.12 教育部“归国留学人员科研启动基金”，2万元，已结题。
9. publications:
一、独立通讯作者文章 （*代表通讯作者，近5年80.711）
1) Zhao Y, Wang Q, Qiu G, Zhou S, Jing Z, Wang J, Wang W, Cao J, Han K, Cheng Q, Shen B, Chen Y, Zhang W, Ma Y, Zhang J*. RACK1 promotes autophagy by enhancing the Atg14L-Beclin 1-Vps34-Vps15 complex formation upon phosphorylation by AMPK. Cell Rep 2015; 13(7):1407-17. 8.358
2) Wang W, Jiang M, Liu S, Zhang S, Liu W, Ma Y, Zhang L, Zhang J*, Cao X*. RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9581-6.
3) Zhu T, Wang J, Pei Y, Wang Q, Wu Y, Qiu G, Zhang D, Lv M, Li W, Zhang J*. Neddylation controls basal MKK7 kinase activity in breast cancer cells. Oncogene 2016; 35(20):2624-33.8.459
4) Wang X, Wang Q, Zhang X, Li Y, Wang J, Hou C, Chen J, Shen B, Shi Y, Zhang J*. Endotoxic shock-expanded murine CD11clowCD45RB+ regulatory dendritic cells modulate inflammatory T cell responses through multiple mechanisms. Sci Reports 2015 May 29;5:10653. doi: 10.1038/srep10653.5.578
5) Wang Q, Zhou S, Wang JY, Cao J, Zhang X, Wang J, Han K, Cheng Q, Qiu G, Zhao Y, Li X, Qiao C, Li Y, Hou C, Zhang J*. RACK1 antagonizes TNF-a-induced cell death by promoting p38 activation. Sci Reports 2015 Sep 18;5:14298. doi: 10.1038/srep14298.5.578
6) Cao J, Zhang X, Wang Q, Qiu G, Hou C, Wang J, Cheng Q, Lan Y, Han H, Shen H, Zhang Y, Yang X, Shen B, Zhang J*. Smad4 represses the generation of memory-precursor effector T cells but is required for the differentiation of central memory T cells. Cell Death Dis 2015 Nov 19; 6:e1984. doi: 10.1038/cddis.2015.337.5.014
7) Han K, Wang Q, Cao H, Qiu G, Cao J, Li X, Wang J, Shen B, Zhang J. The NEDD-activating enzyme inhibitor MLN4924 induces G2 arrest and apoptosis in T-cell acute lymphoblastic leukemia. Oncotarget 2016; 7(17);23812-24. 6.359
8) Zhang X, Ye Z, Pei Y, Qiu G, Wang Q, Xu Y, Shen B, Zhang J*. Neddylation is required for herpes simplex virus type I (HSV-1)-induced early phase interferon-beta production. Cell Mol immunol 2016 Sep; 13(5): 578-83.4.112
9) Zhang D, Wang Q, Zhu T, Cao J, Zhang X, Wang J, Wang X, Li Y, Shen B, Zhang J*. RACK1 promotes the proliferation of THP1 acute myeloid leukemia cells. Mol Cell Biochem 2013;384(1-2):197-202.2.388
10) Cao J, Zhang X, Wang Q, Wang X, Jin J, Zhu T, Zhang D, Wang W, Li X, Li Y, Shen B, Zhang J*. Cyclic AMP suppresses TGF-β-mediated adaptive Tregs differentiation through inhibiting the activation of ERK and JNK. Cell Immunol 2013; 285(1-2):42-8.1.874
11) Zhang J*, Shen B. SHP limits TLR signaling, an inducible transcriptional cprepressor. Cell Mol Immunol 2011; 8(6): 445-6.2.992
12) Zhang J*, Wang Q, Zhu N, Yu M, Shen B, Xiang J, Lin A. Cyclic AMP inhibits JNK activation by CREB-mediated induction of c-FLIPL and MKP-1, thereby antagonizing UV-induced apoptosis. Cell Death Differ 2008; 15: 1654-62.2008年: 影响因子:8.254
13) Zhang J*, Shen B, Lin A. Novel strategies for inhibition of the p38 MAPK pathway. Trends Pharmacol Sci. 2007; 28: 286-95.10.4
14) Wang J, Minemoto Y, Lin A, Li Y, Shen B, Zhang J*. IKK antagonizes CD95 ligation-mediated apoptosis by regulating NF-kB activity. Mol Immunol 2007; 44: 2139-43.4.768
二、合作通讯作者文章 （*代表通讯作者）
1) Guo Y, Wang W, Wang J, Feng J, Wang Q, Jin J, Lv M, Li X, Li Y, Ma Y*, Shen B*, Zhang J*. Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity. Hepatology 2013; 57(1): 140-51.11.19
2) Wang Q, Feng J, Wang J, Zhang X, Zhang D, Zhu T, Wang W, Wang X, Jin J, Cao J, Li X, Peng H, Li Y*, Shen B, Zhang J*. Disruption of TAB1/p38α interaction using a cell-permeable peptide limits myocardial ischemia/reperfusion injury. Mol Ther 2013; 21(9):1668-77.6.425
3) Jin J, Wang X, Wang Q, Guo X, Cao J, Zhang X, Zhu T, Zhang D, Wang W, Wang J, Shen B, Gao X*, Shi Y*, Zhang J*. Chronic psychological stress induces the accumulation of myeloid-derived suppressor cells in mice. PLoS One 2013; 8(9):e74497.3.534
4) Guo X, Zhang X, Li Y, Guo Y, Wang J, Li Y, Shen B, Sun D*, Zhang J*. Nocodazole increases the ERK activity to enhance MKP-1 expression which inhibits p38 activation induced by TNF-a. Mol Cell Biochem 2012; 364: 373-80. 2.329
5) Li YJ, Li XY, Guo XR, Li Y, Shen BF, Shi YC*, Zhang JY*. Absence of SH2B3 mutation in nonobese diabetic mice. Genet Mol Res 2012; 11: 1266-71.0.994
6) Wang J, Tang R, Lv M, Wang Q, Zhang X, Guo Y, Chang H, Qiao C, Xiao H, Li X, Li Y, Shen B*, Zhang J*. Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis. Mol Biol Cell 2011; 22: 117-27.5.527
7) Cui J, Wang Q, Wang J, Lv M, Zhu N, Li Y, Feng J*, Shen B, Zhang J*. Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells. Mol Cancer Ther 2009; 8: 3214-22.4.953
三、共同通讯作者文章 （*代表通讯作者）
1) Zhang J*, Zhu N, Wang Q, Wang J, Ma Y, Qiao C, Li Y, Li X, Su B, Shen B*. MEKK3 over-expression contributes to the hyper-responsiveness of IL-12-overproducing cells and CD4+ T conventional cells in NOD mice. J Immunol 2010; 185: 3554-63. 5.788
2) Wang J, Tang R, Lv M, Zhang J*, Shen B*. Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-a-induced cell death. Mol Cancer 2010; 9:6. 4.768
3) Cui J, Zhu N, Wang Q, Yu M, Feng J, Li Y, Zhang J*, Shen B*. p38 MAPK contributes to CD54 expression and the enhancement of phagocytic activity during macrophage development. Cell Immunol 2009; 256: 6-11. 1.893
四、第一作者文章 （*代表通讯作者）
1. Zhang J, Bui TN, Xiang J, Lin A*. cAMP inhibits p38 activation via CREB-induced Dynein light chain. Mol Cell Biol 2006；26：1223-34. (IF: 7.093)
2. Zhang J, Liu J, Yu C, Lin A. BAD Ser128 is not phosphorylated by c-Jun NH2-terminal kinase for promoting apoptosis. Cancer Res 2005; 65: 8372-8. (IF: 7.616)
3. Yu C#, Minemoto Y#, Zhang J#, Liu J#, Tang F, Bui TN, Xiang J, Lin A. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 2004; 13: 329-40. (IF: 16.811) (#Equal contribution)
4. Zhang J, Li Y, Yu M, Chen B, Shen B. Lineage-dependent NF-κB activation contributes to the resistance of human macrophages to apoptosis. Hematol J 2003; 4: 277-84.
5. Zhang JY, Li Y, Shen BF. PI3-K/Akt pathway contributes to IL-6-dependent growth of 7TD1 cells. Cancer Cell Int 2003; 3:1.1.973
6. Zhang J, Li Y, Shen B. Up-regulation of XIAP by M-CSF is associated with resistance of myeloid leukemia cells to apoptosis. Leukemia 2002; 16: 2163-5. (IF: 4.293)
7. Zhang J, Li Y, Sun Y, Shen B. MEK inhibitor augments IL-6-induced growth arrest and apoptosis, but antagonizes IL-6-induced macrophage differentiation of M1 cells, Immunol Lett 2001; 77: 165-7. (IF: 1.546)
8. Zhang J, Shen B, Li Y, Sun Y. STAT3 exerts two-way regulation in the biological effects of IL-6 in M1 leukemia cells. Leuk Res 2001; 25: 463-72. (IF: 1.502)
9. Zhang J, Shen B. Phosphatidylinositol-3 kinase contributes to the activation of Stat3 in M1 leukemia cells induced by IL-6. ACTA BIOCH BIOPH SIN 2000; 32: 406-8. (IF: 0.289)
10. Zhang J, Li Y, Sun Y, Shen B. Effects of STAT3 antisense RNA on IL-6-induced differentiation and growth arrest of M1 leukemia cells. Prog Nat Sci 2000; 10: 837-42. (IF: 0.249)
五、共同作者文章：
1. Zhang X, Cao J, Pei Y, Zhang J, Wang Q. Smad4 inhibits cell migration via suppression of JNK activity in human pancreatic carcinoma PANC-1 cells. Oncol Lett. 2016 May;11(5):3465-3470.
2. Zhao Y, Zhu T, Zhang X, Wang Q, Zhang J, Ji W, Ma Y. Splicing factor 2/alternative splicing factor contributes to extracellular signal-regulated kinase activation in hepatocellular carcinoma cells. Mol Med Rep 2015 sep; 1293):3890-4. (IF:1.554)
3. Yan J, Xiang J, Lin Y, Ma J, Zhang J, Zhang H, Sun J, Danial NN, Liu J, Lin A. Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation. Cell 2013;152(1-2):304-15（IF：33.116）.
4. Wang J, Guo X, Cao J, Zhang X, Zhang J, Sun D, Wang Q. Prolonged pretreatment of mice with cholera toxin, but not isoproterenol, alleviates acute lethal systemic inflammatory response. Int Immunopharmacol 2014;23(1):60-5（IF:2.472）.
5. Wang X, Li Y, Xiao H, Zhang X, Cao J, Zhang D, Zhang J, Li X, Shen B, Wang Q*, Shi Y*. Co-culture of spleen stromal cells with bone marrow mononuclear cells leads to the generation of a novel macrophage subset. Scand J Immunol 2014;79(1):27-36.(IF:1.739)
6. Wang JY, Chen J, Zhang J, Pu CQ*. Vitamin D Receptor mRNA Expression From Muscle Tissue is Significantly Different Between Idiopathic Inflammatory Myopathy and Limb-girdle Muscular Dystrophy Type 2B Patients. J NEUROL SCI-TURK 2014; 31(2): 325-34.(IF:0.105)
7. Qiao C, Lv M, Li X, Geng J, Li Y, Zhang J, Lin Z, Feng J, Shen B. Affinity maturation of antiHER2 monoclonal antibody MIL5 using an epitope-specific synthetic phage library by computational design. J Biomol Struct Dyn 2013; 31: 511-21.(IF:2.983)
8. Yan XL, Lan Y, Wang XY, He WY, Yao HY, Chen DB, Xiong JX, Gao J, Li Z, Yang G, Li XS, Liu YL, Zhang JY, Liu B, Mao N. Migration of dorsal aorta mesenchymal stem cells induced by mouse embryonic circulation. Dev Dyn 2011; 240: 65-74. (IF: 2.536)
9. He WY, Lan Y, Yao HY, Li Z, Wang XY, Li XS, Zhang JY, Zhang Y, Liu B, Mao N. Interleukin-3 promotes hemangioblast development in mouse aorta-gonad-mesonephros region. Haematologica 2010; 95: 875-83. (IF: 6.13)
10. Cao G, Huang B, Liu Z, Zhang J, Xu H, Xia W, Li J, Li S, Chen L, Ding H, Zhao Q, Fan M, Shen B, Shao N. Intronic miR-301 feedback regulates its host gene, ska2, in A549 cells by targeting MEOX2 to affect ERK/CREB pathways. Biochem Biophys Res Commun 2010; 396: 978-82. (IF: 2.595)
11. Li HY, Liu H, Wang CH, Zhang JY, Man JH, Gao YF, Zhang PJ, Li WH, Zhao J, Pan X, Zhou T, Gong WL, Li AL, Zhang XM. Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1. Nat Immunol 2008; 9: 533-41. (IF: 25.668)
12. Zhu N, Cui J, Qiao C, Li Y, Ma Y, Zhang J, Shen B. cAMP modulates macrophage development by suppressing M-CSF-induced MAPKs activation. Cell Mol Immunol 2008; 5: 153-7. (IF: 2.026)
13. Wang Y, Zhao K, Chen J, Zhang J, Yu M, Li Y, Shen B. The characteristic of an anti-human DR5 antibody A6. Cell Mol Immunol 2008; 5: 183-8. (IF: 2.026)
14. Chang H, Qin W, Li Y, Zhang J, Lin Z, Lv M, Sun Y Feng J, Shen B. A novel human scFv fragment against TNF-a from de novo design method. Mol Immunol ; 2007; 44: 3789-96. 4.768
15. Xia Q, Wang H, Wang J, Zhang J, Liu B, Li A, Lv M, Hu M, Yu M, Feng J, Yang S, Zhang X, Shen B. Proteomic analysis of interleukin 6-induced differentiation in mouse myeloid leukemia cells. Int J Biochem Cell Biol 2005; 37: 1197-207. (IF: 4.956)
