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研究人员

王泽坤

2018年12月03日         作者:         访问:[]

http://bms.henu.edu.cn/__local/B/78/AB/D5F6C80493C4D1CA6B27EE62A63_185DEFBF_8C32.jpg

王泽坤,男,博士,2018年6月受聘河南大学杰出人才特区支持计划第四层次特聘教授。2006年7月毕业于河北大学生命科学学院生物技术专业获学士学位;2011年6月毕业于复旦大学上海医学院医学分子病毒学教育部、卫计委重点实验室获病原生物学博士学位;2011年7月至2012年9月受聘上海交通大学、上海市肿瘤研究所癌基因及相关基因国家重点实验室,任助理研究员;2012年9月至2018年6在美国堪萨斯大学医学中心微生物与免疫学系从事博士后研究;2018年6月入职河南大学基础医学院,现为河南大学抗体药物开发技术国家地方联合工程实验室生物治疗方向主要负责人。

二、主要研究方向

遗传性疾病和持续性感染疾病的基因治疗与基因编辑,病毒载体分子生物学,乙型肝炎病毒、新发布尼亚病毒等重要病原体的复制和致病机理。

三、已发表的论文

1.Zekun Wang,Xuefeng Deng, Wei Zou, John Engelhardt, Ziying Yan, JianmingQiu. Human Bocavirus 1 Is a Novel Helper for Adeno-Associate Virus Replication.Journal of virology. September 2017 vol. 91 no. 18 e00710-17(当期亮点论文)

2.Zekun Wang,Weiran Shen, Fang Cheng, Xuefeng Deng, John Engelhardt, Ziying Yan and JianmingQiu. Parvovirus expresses a small noncoding RNA that plays an essential role in virus replication.Journal of virology.April 2017 vol. 91 no. 8e02375-16.(当期亮点论文)

3.Zekun Wang,Mohammad A Mir. Andes virus nucleocapsid protein interrupts protein kinase R dimerization to counteract host interference in viral protein synthesis.Journal of virology.February 2015 vol. 89 no. 3 1628-1639.

4.Zekun Wang,Jinjing Ni, Jianhua Li, Bisheng Shi, Yang Xu, Zhenghong Yuan. Inhibition of hepatitis B virus replication by cIAP2 involves accelerating the ubiquitin proteasome mediated destruction of polymerase.Journal of virology. November 2011 vol. 85 no. 21 11457-11467.

5. Wei Zou,Zekun Wang, Min Xiong, Aaron Chen, Peng Xu, SafderGanaie, YomnaBadawi, Steve Kleiboeker, Hiroshi Nishimune, Shui Qing Ye, and JianmingQiu. Human Parvovirus B19 Utilizes Cellular DNA Replication Machinery for Viral DNA Replication.Journal of virology. 2018 Feb 12;92(5). e01881-17.

6. Wang Y,Wang Z, Pramanik A, Santiago ML, Qiu J, Stephens EB. A chimeric human APOBEC3A protein with a three amino acid insertion confers differential HIV-1 and adeno-associated virus restriction.Virology. 2016 Aug 29; 498: 149-163.

7. Erdong Cheng,Zekun Wangand Mohammad A Mir. Interaction between Hantavirus Nucleocapsid Protein (N) and RNA Dependent RNA Polymerase (RdRp) mutant reveals the requirement of N-RdRp interaction for Viral RNA Synthesis.Journal of virology. August 2014 vol. 88 no. 15 8706-8712.

8. Xuefeng Deng, Wei Zou, Min Xiong,Zekun Wang, John F. Engelhardt, Shui Qing Ye, Ziying Yan, JianmingQiu. Human Parvovirus Infection of Human Airway Epithelia Induces Pyroptotic Cell Death via Inhibiting Apoptosis.Journal of virology.2017 Nov 30;91(24). e01533-17.

9. Ziying Yan, Zehua Feng, Xingshen Sun, Yulong Zhang, Wei Zou,Zekun Wang, Chandler Jensen-Cody, Bo Liang, Soo-Yeun Park, JianmingQiu, John F Engelhardt. Human Bocavirus Type-1 Capsid Facilitates the Transduction of Ferret Airways by Adeno-Associated Virus Genomes.Human Gene Therapy. August 2017, 28(8): 612-625.

10. Jianhua Li, Yinghui Liu,Zekun Wang, Kuancheng Liu, Yaohui Wang, Jiangxia Liu, Huanping Ding, Zhenghong Yuan. Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment.Journal of virology. July 2011 vol. 85 no. 13 6319-6333.

11. Qi-Ying Chen, Ying-Hui Liu, Jian-Hua Li,Ze-Kun Wang, Jiang-Xia Liu, Zheng-Hong Yuan. DNA-dependent activator of interferon-regulatory factors inhibits hepatitis B virus replication.World J Gastroenterology2012 June 14; 18(22): 2850-2858.

12. GuanglinBian, Yuming Cheng,Zekun Wang, Yunwen Hu, Xiaonan Zhang, Min Wu, Zhiao Chen, Bisheng Shi, Shuhui Sun, Yan Shen, Erjia Chen, Xin Yao,Yumei Wen, Zhenghong Yuan. Whole recombinant Hansenulapolymorpha expressing hepatitis B virus surface antigen (yeast-HBsAg) induces potent HBsAg-specific Th1 and Th2 immune responses.Vaccine28:187-94.

四、参加国际学术会议及相关奖励:

2018.5.16-19第21届美国基因与细胞治疗学会年会芝加哥大会报告(获当期大会资助奖)

2017.5.8-12第20届美国基因与细胞治疗学会年会华盛顿

2017.6.24-28第36届美国病毒学会年会威斯康星-麦迪逊大会报告

2015.7.11-15第34届美国病毒学会年会加拿大安大略大会报告(获当期大会资助奖)

2009年9月第25届乙型肝炎病毒分子生物学国际会议法国图尔斯墙报

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